关键词: 受体, 肾上腺素能β_2<, sub>, 基因, 聚合酶链反应

Abstract: Objective To investigate the association of beta 2 adrenergic receptor (β₂AR) gene with asthma in children. Methods The 5′ 234 bp fragment of β₂AR gene was analyzed by PCR method. Results The fragment deletion of β₂AR existed in 22 cases of 65 asthmatic patients and in 6 cases of 20 healthy clildren in control group, the deletion rates were 33.8% and 30%，respectively . There was no significant difference between the two groups. The deletion rate of β₂AR gene fragment in severe asthma group was higher than that in mild-moderate asthma group. Conclusion The deletion of this fragment of β₂AR gene isn′t related to onset of asthma, but it is related to onset of severe asthma.

Key words: receptors, adrenergic, beta-2, gene, polymerase chain reaction