关键词: 治疗应用, 冠状动脉疾病, 药物疗法, 超氧化物歧化酶, 血液, 丙二醛, 血液, 活性氧

Abstract: Objective To observe the effects of complex pharmaceutics containing carnitine and eortcd on oxygen free radical (OFR) activity in acute coronary syndrome (ACS) patients. Methods Forty patients with ACS were divided into two groups randomly：carnitine and eortcd therapy group (A group, 20 cases) and routine therapy group (B group ,20 cases). 20 healthy blood donors were served as control (C group).Patients in A group were given carnitine and eortcd 10 mL ,bid p.o., twice a day for 30 days, and other administrations were the same as B group. The levels of serum SOD and MDA in A and B group before and after therapy were detected. Results The levels of serum SOD in A group before therapy and B group before and after therapy were lower than that in C group (P<0.01)，there was no diffence between A group after therapy and C group, as well as A and B group before therapy (P>0.05). After therapy, A group was higher than B group. The concentration of MDA in A and B groups were higher than that in C group (P<0.01).The level of serum SOD in A group increased significantly after therapy (P<0.05), there was no significant difference in B group before and after therapy (P<0.05); the MDA in A and B groups decreased markedly after therapy, compared with C group (P>0.01), before and after therapy, there was no significant difference between A and B group (P>0.05). The levels of serum MDA after therapy in A and B group were lower than before therapy (P<0.01), however, they were higher than C group. Conclusion Canitine and eortcd can alleviate the injury of OFR and has protective function on ischemic myocardium in ACS patients.

Key words: therapeutic use, coronary disease, drug therapy, superoxide dismutase, blood, malondialdehyde, blood, reactive oxygen species