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• 基础研究 • 上一篇    下一篇

高压静电场对发育小鼠生理及生化指标的影响

邢沈阳1,孙 寒2,梁重阳3,衣同辉3, 孙 非3*   

  1. 1. 吉林大学护理学院普通课教研室, 吉林 长春130021;2. 吉林大学第二医院消化内科,吉林 长春130041;3. 吉林大学再生医学科学研究所细胞生物研究室,吉林 长春130021
  • 收稿日期:2005-04-08 修回日期:1900-01-01 出版日期:2005-11-28 发布日期:2005-11-28
  • 通讯作者: 孙 非

Effect of high voltage electrostatic field on physiological and biochemistry indexes in developmental mice

XING Shen-yang1, SUN Han2,LIANG Chong-yang3,YI Tong-hui3,SUN Fei3*   

  1. 1. Department of Common Lesson, School of Nursing, Jilin University,Changchun 130021,China;2. Department of Digestive Medicine,Second Hospital,Jilin University,Changchun 130041,China;3. Department of Cytobiology,Institute of Frontier Medical Sciences, Jilin University,Changchun 130021,China
  • Received:2005-04-08 Revised:1900-01-01 Online:2005-11-28 Published:2005-11-28
  • Contact: SUN Fei

摘要: 目的:探讨不同强度高压静电场(HVEF)对动物机体生理功能的影响。方法:昆明种小鼠150只,随机分为 5组(每组30只),分别设非静电场处理组(CK)、HVEF0.6、1.2、1.8和2.4 kV·cm-1处理组,测定不同强度HVEF下饲养的小鼠在发育过程中多种生理生化指标的变化。结果:一定强度HVEF具有促进小鼠生长的作用,其阈值为 0.6 kV·cm-1。在这个电场强度处理下,小鼠体重明显增加;心肌细胞和肝细胞中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性升高;脂质过氧化物(LPO)的含量下降,与CK组比较差异有显著性(P<0.01);心脏和肝脏多种生化酶指标均正常。结论:HVEF对小鼠发育的促进作用不是对某一代谢机制的单独作用,而是整体机能协同作用 的结果,适宜的HVEF对多种疾病的康复是有益的。

关键词: 生物物理学, 超氧化物歧化酶, 分析, 谷胱甘肽过氧化物酶, 分析, 过氧化脂质类, 分析, 模型, 动物, 小鼠

Abstract: Objective To discuss the effects of different intensity of HVEF on physiological function of animal organism.Methods 150 Kunming mice were randomly divided into five groups with 30 animals in each group: normal control group, four experimental groups treated with 0.6, 1.2, 1.8 and 2.4 kV·cm-1 HVEF, respectively. The variation of physiological and biochemistry indexes in the developmental pr ocess of mice which underwent different intensity of HVEF were measured. Results HVEF with a certain intensity could promote mouse development, the threshold value was 0.6 kV·cm-1 . Treated with this intensity,HVEF could increase the weight of mice and the activities of SOD and GSH-Px in both cardiac muscle cells and hepatocytes, and decreased the content of LPO, compared with control group, the difference was significant (P<0.01). HVEF pro moted the metabolism by regulating the activities of various enzymes. Conclusion HVEF can improve mouse development not only by single effect on some metabolism mechanism, but also by the coordination of the whole organism,the suitable HVEF is of benefit to rehabilitation process of many kinds of diseases.

Key words: biophysics, superoxide dismutase, analysis, glutathione peroxidase, analysis, lipid peroxides, analysis, models, animal, mice

中图分类号: 

  • Q689