Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (6): 1429-1436.doi: 10.13481/j.1671-587X.20210612
• Research in basic medicine • Previous Articles Next Articles
Xiaolei XU1,Yukun YANG1,Zhongming LI1,Xinyue LI1,Ying WANG1,Jie SHENG1,Jing ZHANG2,Xiuling SUN2,Hongyan WANG2,Li QU2,Huan LI2()
Received:
2021-05-24
Online:
2021-11-28
Published:
2021-12-14
Contact:
Huan LI
E-mail:326002885@qq.com
CLC Number:
Xiaolei XU,Yukun YANG,Zhongming LI,Xinyue LI,Ying WANG,Jie SHENG,Jing ZHANG,Xiuling SUN,Hongyan WANG,Li QU,Huan LI. Improvement effect of ginsenoside Rg3 on reproductive function injury induced by dibutyl phthalate in mice and its mechanism[J].Journal of Jilin University(Medicine Edition), 2021, 47(6): 1429-1436.
1 | 李青花. 环境因素导致男性不育症的机理探讨[J]. 中国计划生育学杂志, 2004, 12(5): 319-320. |
2 | ZHOU S H, DENG Y F, WENG Z W, et al. Traditional Chinese medicine as a remedy for male infertility: a review[J]. World J Mens Health, 2019, 37(2): 175-185. |
3 | 王晓英, 张均田. 人参皂苷Rb1对小鼠性功能的改善作用及其机制探讨[J]. 药学学报, 2000, 35(7): 492-495. |
4 | PARK J S, HWANG S Y, LEE W S, et al. The therapeutic effect of tissue cultured root of wildPanax ginseng C.A. Mayer on spermatogenetic disorder[J]. Arch Pharmacal Res, 2006, 29(9): 800-807. |
5 | CAO Y, YE Q, ZHUANG M F, et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway[J]. PLoS One, 2017, 12(11): e0186520. |
6 | LIANG H, ZHANG S, LI Z. Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a[J]. Drug Des Devel Ther, 2019, 13: 2057-2066. |
7 | 李 环, 钱鸿昊, 徐小磊, 等. 人参皂苷3(Rg3)通过GJIC发挥生精保护作用的研究[J]. 中华中医药学刊, 2020, 38(12): 241-244, 290. |
8 | KOPALLI S R, HWANG S Y, WON Y J, et al. Korean red ginseng extract rejuvenates testicular ineffectiveness and sperm maturation process in aged rats by regulating redox proteins and oxidative defense mechanisms[J]. Exp Gerontol, 2015, 69: 94-102. |
9 | LARA N L M, DRIESCHE SVAN D E N, MACPHERSON S, et al. Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats[J]. Sci Rep, 2017, 7(1): 2521. |
10 | WANG H Y, ZHOU W P, ZHANG J, et al. Role of JNK and ERK1/2 MAPK signaling pathway in testicular injury of rats induced by di-N-butyl-phthalate (DBP)[J]. Biol Res, 2019, 52: 41. |
11 | 杨 阳,刘福荣,崔留欣,等.PM2.5暴露对雄性大鼠生殖功能及IRE1-JNK通路相关蛋白表达的影响[J].郑州大学学报(医学版),2021,56(3):309-313. |
12 | 许慧. 人参皂苷Rg1及其代谢产物Rh1、Ppt生精保护作用的分子机制研究[D]. 开封: 河南大学, 2013. |
13 | GERBER J, HEINRICH J, BREHM R. Blood-testis barrier and sertoli cell function: lessons from SCCx43KO mice[J]. Reproduction, 2016, 151(2): R15-R27. |
14 | DOLATI P, KHODABANDEH Z, ZAMIRI M J,et al. The effect of lead acetate and quercetin on the tight and gap junctions in the mouse testis[J]. Biol Trace Elem Res, 2020, 198(2): 535-543. |
15 | XIA Q, ZHANG D, WANG J, et al. Androgen indirectly regulates gap junction component connexin 43 through wilms tumor-1 in Sertoli cells[J]. Stem Cells Dev, 2020, 29(3): 169-176. |
16 | LI M W, MRUK D D, CHENG C Y. Gap junctions and blood-tissue barriers[J]. Adv Exp Med Biol, 2012, 763: 260-280. |
17 | ZHANG J, ZHANG Y, ZHAO J C, et al. PGE2 regulating Cx43 to affect testosterone synthesis in rats leydig cell exposed at DBP[J]. Int J Clin Exp Pathol, 2016, 9(4): 4574-4578. |
18 | 张 燚, 李 环. DBP介导cx43对大鼠睾丸leydig细胞睾酮合成的影响[J]. 北华大学学报(自然科学版), 2015, 16(2): 191-194. |
19 | BACARIZO J, MARTINEZ-RODRIGUEZ S, MARTIN-GARCIA J M, et al. Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation[J]. PLoS One, 2014, 9(12): e113224. |
20 | CORDERO J B, RIDGWAY R A, VALERI N, et al. C-Src drives intestinal regeneration and transformation[J]. EMBO J, 2014, 33(13):1474-1491. |
21 | MATOZAKI T, KOTANI T, MURATA Y, et al. Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis[J]. Cancer Sci, 2021, 112(1): 16-21. |
22 | GUO J R, LI R, XU Z Y, et al. Upregulated lnc-HZ02 and miR-hz02 inhibited migration and invasion by downregulating the FAK/SRC/PI3K/AKT pathway in BPDE-treated trophoblast cells[J]. J Biochem Mol Toxicol, 2021, 35: e2275. |
23 | LIU H, WU Y, ZHU S, et al. PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer[J]. Cancer Lett, 2015, 359(2): 218-225. |
24 | XU X, QU Z, QIAN H, et al. Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di-N-butyl-phthalate[J]. Environ Toxicol, 2021, 36(5): 789-799. |
25 | CHENG C Y, MRUK D D. The blood-testis barrier and its implications for male contraception[J]. Pharmacol Rev, 2012, 64(1): 16-64. |
26 | GANGOSO E, THIRANT C, CHNEIWEISS H,et al. A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype[J]. Cell Death Dis, 2014, 5: e1023. |
27 | GANGOSO E, TALAVERÓN R, JARAÍZ-RODRÍGUEZ M, et al. A c-src inhibitor peptide based on Connexin43 exerts neuroprotective effects through the inhibition of glial hemichannel activity[J]. Front Mol Neurosci, 2017, 10: 418. |
[1] | Mengyao SHAN,Weigang WANG,Jinxiang DONG,Jianming TIAN,Lianlian SONG,Yinghong CHEN,Xiaoxue FANG,Zhidong QIU,Haoming LUO,Difu ZHU. Improvement effect of Panax ginseng glycoproteins on spermatogenesis of mice with oligoasthenozoospermia [J]. Journal of Jilin University(Medicine Edition), 2022, 48(3): 575-583. |
[2] | Bingxue QI,Yangwei WANG,Yixian ZHANG,Jingbo ZHAO,Yan MA,Yadong SUN. Ameliorative effect of liraglutide on renal function and podocyte injury of rats with diabetic nephropathy and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2022, 48(2): 331-339. |
[3] | Chunxu LIU,Hongxia SUN,Bo HU,Enping JIANG. Inhibitory effects of Schisandrin B on cardiac fibroblast proliferation and its PI3K/Akt/P27kip1 signaling pathway mechanism [J]. Journal of Jilin University(Medicine Edition), 2022, 48(1): 52-58. |
[4] | Jingjing MA,Yu LIU,Yan LIANG,Ying LI. Promotion effect of total alkaloids of leonurus on decidual villus excretion in drug abortion rats and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(6): 1476-1484. |
[5] | Yingying SHI,Shitong CHEN,Bo HU,Duo SHEN,Kuang ZHU,Siwei YE,Jinmei FENG. Induction of 3C protein of Coxsackievirus A16 in apoptosis of human rhabdomyosarcoma cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(4): 874-881. |
[6] | Jie YANG,Wubin HE,Ni AN,Wencong KONG,Rongjian SU,Xuezhe WANG. Regulatory effect of glucose-regulating protein 78 on radiotherapy sensitivity of liver cancer cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(4): 888-895. |
[7] | Nuan WANG,Lijuan YANG,Juanjuan DAI,Aili WANG,Yan WU,Chengxia LIU. Promotion effects of MARCH1 on migration and invasion of human gastric cancer cells through PI3K/AKT signaling pathway [J]. Journal of Jilin University(Medicine Edition), 2021, 47(2): 352-359. |
[8] | Bingxue QI,Yan MA,Yixian ZHANG,Yadong SUN,Lining MIAO. Effect of liraglutide on expressions of mRNA and protein of related proteins after podocyte injury induced by high glucose and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(2): 275-283. |
[9] | . Inhibitory effect of curcumin on tumor growth in colorectal cancer mice and its mechanism of PTEN/PI3K/Akt signaling pathwayPEI Yongbin, WANG Guiqi, LI Wei, JIANG Xia, JIANG Haibo, ZHAO Zengren (Department of General Surgery,First Hospital,Hebei Medical University, Shijiazhuang 050031,China) [J]. Journal of Jilin University(Medicine Edition), 2021, 47(1): 145-151. |
[10] | Meijuan LU,Xiande MA,Lu REN. Effect of acupuncture combined with medicine-induced autophagy on cognitive function of mice with ApoE gene knockout [J]. Journal of Jilin University(Medicine Edition), 2020, 46(6): 1124-1130. |
[11] | Ye LIU,Longyun CHEN. Effect of astragalus polysaccharide on cisplatin resistance of human lung cancer A549/DDP cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2020, 46(6): 1162-1168. |
[12] | Jing LIU,Lijun YAN. Effects of triptolide on angiogenesis and PTEN / PI3K / AKT pathway in model rats with rheumatoid arthritis [J]. Journal of Jilin University(Medicine Edition), 2020, 46(6): 1227-1233. |
[13] | Xia WANG,Yujun YAO,Jing TANG,Kaihui LI. Effect of lncRNA-CCAT2 on apoptosis of cervical cancer CaSki cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2020, 46(6): 1247-1253. |
[14] | JIA Daqi, KONG Wencong, SU Rongjian, DU Xiaoyuan, HE Wubin. Effects of macrophage stimulating 1 receptor inhibitor BMS777607 on proliferation and apoptosis of lung cancer cells [J]. Journal of Jilin University(Medicine Edition), 2020, 46(04): 739-744. |
[15] | LI Huan, QU Zhenting, QIAN Honghao, XU Han, QU Li, ZHANG Jing, WANG Hongyan, XU Xiaolei. Improvement effect of ginsenoside Rg1 combined with ginsenoside Rg3 on reproductive function in male model mice with reproductive function injury [J]. Journal of Jilin University(Medicine Edition), 2020, 46(04): 707-713. |