Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (6): 1485-1494.doi: 10.13481/j.1671-587X.20210619
• Research in basic medicine • Previous Articles Next Articles
Feng ZHAO1(),Shaoqing FAN1,Xiaoyan CHENG1,Xiaona LI1,Changsheng LI2,Haojie MA1
Received:
2021-02-01
Online:
2021-11-28
Published:
2021-12-14
Contact:
Feng ZHAO
E-mail:lmlm20@163.com
CLC Number:
Feng ZHAO,Shaoqing FAN,Xiaoyan CHENG,Xiaona LI,Changsheng LI,Haojie MA. Effect of intrathecal injection of transient receptor potential cation channel subfamily A member 1 shRNA on neuropathic pain in mice with partial sciatic nerve ligation and its mechanism[J].Journal of Jilin University(Medicine Edition), 2021, 47(6): 1485-1494.
Tab.1
MWT of mice in various groups"
Group | MWT | ||||
---|---|---|---|---|---|
Before injection | 1 h after injection | 7 h after injection | 12 h after injection | 24 h after injection | |
Control | 11.51±0.80 | 11.70±0.21 | 11.06±0.45 | 10.81±0.35 | 11.62±0.34 |
Sham operation | 11.20±0.68 | 11.82±0.25 | 10.80±0.31 | 11.22±0.43 | 11.31±0.14 |
pSNL | 5.62±0.33* | 5.53±0.25* | 5.72±0.13* | 5.51±0.32** | 4.84±0.69* |
pSNL+NC shRNA | 5.82±0.42* | 5.73±0.33* | 5.52±0.43* | 5.81±0.63** | 4.55±0.38* |
pSNL+TRPA1 shRNA | 5.53±0.28* | 9.31±0.13*△# | 10.22±0.42△# | 10.73±0.48△# | 10.90±0.13△# |
Tab. 2
TWL of mice in various groups"
Group | TWL | ||||
---|---|---|---|---|---|
Before injection | 1 h after injection | 7 h after injection | 12 h after injection | 24 h after injection | |
Control | 18.52±0.90 | 17.71±0.19 | 17.20±0.25 | 16.83±0.51 | 17.64±0.43 |
Sham operation | 18.20±0.76 | 17.81±0.65 | 17.80±0.11 | 17.22±0.46 | 18.03±0.12 |
pSNL | 11.04±0.22* | 10.91±0.12* | 10.33±0.35* | 10.52±0.65* | 8.73±0.52* |
pSNL+NC shRNA | 10.81±0.32* | 10.74±0.31* | 10.40±0.53* | 10.31±0.53* | 8.53±0.34* |
pSNL+TRPA1 shRNA | 10.50±0.18* | 16.33±0.23* | 16.52±0.51*△# | 16.81±0.55△# | 17.63±0.63△# |
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