冠心病住院患者生命质量相关影响因素分析

doi:10.13481/j.1671-587X.20220226

Abstract

Abstract: Objective

To analyze the general demographic characteristics， psychological distress， laboratory and imaging results of inpatients with coronary heart disease （CHD），and to explore the influence in the life quality of patients.

Methods

The European Quality of Life-5 Dimensions （EQ-5D） and Visual Analogue Scale （VAS） were used to evaluate the life quality of 367 hospitalized CHD patients who met the inclusion and exclusion criteria. The differences of life qualities among different population characteristics were compared；Perceived Social Support Scale （PSSS）， General Anxitey Disdorde -7 （GAD-7） and Patient Health Questionnaire-9 （PHQ-9） were used to investigate the life quality. Meanwhile， the clinical laboratory examination and imaging data were collected， and Tobit regression analysis and linear regression analysis were carried out to analyze the independent influencing factors of the life quality scores.

Results

The Tobit regression analysis results showed education level， marital status， depression level and D-dimer（D-D） level were the independent influencing factors of EQ-5D score of CHD inpatients.The EQ-5D of health utility value patients with low education level （illiteracy，P<0.01， 95% CI：－0.24－－0.06； primary school culture， P<0.01， 95% CI：－0.28－－0.11； junior high school education，P<0.01， 95% CI：－2.22－－0.03） was lower. Compared with the widowed CHD inpatients，the EQ-5D health efficacies of unmarried （P<0.01， 95% CI： 0.07－0.33） and married （P<0.01， 95% CI： 0.05－0.21） CHD inpatients were higher.The patients with high depression scores （depressive symptoms， P<0.01， 95% CI：－0.16－－0.05； obvious depressive symptoms P<0.01， 95% CI：－0.21－－0.08； severe depression， P<0.01， 95% CI：－0.27－－0.13） had lower EQ-5D health efficacies； the CHD inpatients with high levels of D-D （P<0.01， 95% CI：－0.11－0.02） had low EQ-5D health efficacy.The general linear regression analysis results showed that marital status （P<0.01， 95% CI：－8.12－－2.38），depression （P<0.01， 95% CI：－7.68－－3.72） and sleep （P<0.01， 95% CI：－7.59－－2.18） were the independent influencing factors of VAS life quality scores of CHD inpatients.

Conclusion

The education level， marital status， depression， sleep quality and D-D level of CHD inpatients are the important influencing factors of life quality.

Key words: Coronary heart disease, Health-related quality of life, Social support, Depression, Sleep, Influencing factor

CLC Number:

R541.4

Cong FU,Yang YANG,Mingtu XU,Zeying QIN,Jingyang LI. Analysis on related influencing factors of life quality of inpatients with coronary heart disease[J].Journal of Jilin University(Medicine Edition), 2022, 48(2): 478-486.

Figures/Tables 3

Tab. 2

Tab. 3

Tab. 4

References 23

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Variable		Value
Demographic characteristics
X1	Gender	0=Male，1=Female
X2	Cultural level	0=Illiteracy，1=Primary school 2=Junior middle school，3=High school，4=University
X3	Income level	0=0－2 000，1=2 001－4 000，2=4 001－6 000，3=6 001－8 000，4=8 000 and above
X4	Marital status	0=Unmarried，1=Married，2=Divorce，3=Widowed
	Health related information
X5	Hypertension	0=No，1=Yes
X6	Diabetes	0=No，1=Yes
X7	Smoking history	0=No，1=Yes
X8	History of alcoholism	0=No，1=Yes
Psychological distress factors
X9	Social support	0=12－36 Low social support，1=37－60 Medium social support， 2=61－84 High social support
X10	Depressed	0=0－4 No depression，1=5－9 Have depressive symptoms， 2=10－14 Obvious depressive symptoms，3=15－27 Severe depression
X11	Anxious	0=0－4 No anxiety，1=5－9 Mild anxiety， 2=10－14 Moderate anxiety，3=15－21 Severe anxiety
X12	Sleep	0=Very good，1=Very light，2=Bad or poor
Laboratory and imaging indexes related to CHD
X13	cTnI	0=0－0.5 g·L^－1，1=Above 0.5 g·L^－1
X14	Myo	0=0－107 μg·L^－1，1=Above 107 μg·L^－1
X15	D-D	0=0－600 g·L^－1，1=Above 600 g·L^－1
X16	BNP	0=0－100 ng·L^－1，1=Above 100 ng·L^－1
X17	LVEDD	0=0－50 mm，1=Above 50 mm
X18	LVEF	0=0%－50%，1=Above 50%

Variable	B	Standard error	t	P	95% CI
Cultural level （Reference group:university)
Llliteracy	－0.15	0.05	－3.34	<0.01	－0.24－－0.06
Primary school	－0.19	0.05	－4.15	<0.01	－0.28－－0.11
Junior middle school	－0.12	0.05	－2.61	<0.01	－2.22－－0.03
High school	－0.39	0.06	－0.71	0.48	－0.14－0.06
Marital status （Reference group:widowed）
Unmarried	0.21	0.07	3.07	<0.01	0.07－0.33
Married	0.12	0.04	3.24	<0.01	0.05－0.21
Divorce	0.04	0.05	0.85	0.39	－0.05－0.14
Depressed (Reference group:no depression)
Have depressive symptoms	－0.11	0.03	－4.08	<0.01	－0.16－－0.05
Obvious depressive symptoms	－0.14	0.03	－4.54	<0.01	－0.21－－0.08
Severe depression	－0.20	0.04	－5.76	<0.01	－0.27－－0.13
LVEDD (Reference group:0=0－50 mm)
Above 50 mm	0.01	0.02	0.32	0.752	－0.04－0.05
D-D (Reference group:0=0－600 g·L^－1)
Above 600 g·L^－1	－0.07	0.02	－3.01	<0.01	－0.11－－0.02

Variable	B	Standard error	t	P	95% CI
Marital status	－5.24	1.46	－3.59	<0.01	－8.12－－2.38
Depressed	－5.70	1.01	－5.67	<0.01	－7.68－－3.72
Sleep	－4.88	1.38	－3.55	<0.01	－7.59－－2.18
LVEF	3.50	2.02	1.73	0.08	－0.47－7.47

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Analysis on related influencing factors of life quality of inpatients with coronary heart disease

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