The clinical data of a patient with bilocular myxoma with palpitations and shortness of breath as the main symptoms was collected，and the relevant clinical characteristics， diagnosis and treatment of the disease were analyzed， and the literatures were reviewed.

The 45-year-old female patient was admitted to the hospital due to the palpitations and shortness of breath for 2 weeks. The color Doppler echocardiography results indicated that substantial echoes were found in both chambers， which were attached to the oval fossa of the atrial septum. The substantial echo size in the right atrial was 43.2 mm×23.8 mm， and the substantial echo size in the left atrial was 43.9 mm×14.5 mm， considering the possibility of bilateral myxoma. Excision of atrial mass was performed through the right atrial approach under cardiopulmonary bypass and general anesthesia within a time limit after the relevant examinations were completed. The postoperative pathological diagnosis was atrial myxoma complicated with extensive infaction and bleeding. The patient was followed up for 1 month， 3 months， 6 months and 12 months after operation， and no recurrence was found in the re-examination of cardiac color ultrasound.

Atrial myxoma is the most common benign cardiac tumor， but bilocular myxoma is particularly rare. Cardiac color ultrasound can confirm the diagnosis， surgical resection is an effective means of treatment， routine pathological examination after operation is useful to exclude the possibility of malignancy， and the patients with atrial myxoma should be followed up for a long time after operation.