脊髓损伤后肠道菌群变化及其对脊髓神经炎症影响的研究进展

doi:10.13481/j.1671-587X.20240630

Abstract

Abstract:

The gut microbiota is a vast microbial ecosystem， specifically present in the organism and plays an important regulatory role in the body’s health or disease state together with its metabolites. After spinal cord injury， the complex pathophysiology at the site of trauma makes axonal regeneration difficult， and the autonomic motor dysfunction induced by spinal cord injury disrupts gastrointestinal function and causes gut microbiota imbalance. The previous clinical outcomes of neurorepair strategies after spinal cord injury have not been ideal. The dysregulated gut microbiota and neuroinflammation after spinal cord injury are closely associated with the prognosis of the patients. The potential mechanisms by which the gut microbiota may influence the neuroinflammation after spinal cord injury may include the activation of gut-associated lymphoid tissue and disruption of the intestinal barrier by the imbalanced microbiota， and gut microbiota and its metabolites such as lipopolysaccharides（LPS）， short chain fatty acids（SCFAs）， 5-hydroxytryptamine（5-HT）， and tryptophan， as well as immune cells， inflammatory factors， and neurotransmitters the local inflammatory response in the spinal cord through the circulatory system. This paper revews the studies on the changes in gut microbiota after spinal cord injury and their effects on the spinal cord neuroinflammation， providing new targets and new ideas for improving the neuroinflammation after spinal cord injury.

Key words: Spinal cord injury, Spinal neuroinflammation, Gut microbiota, Metabolism

CLC Number:

R744

Haixia CHEN,Hongru LI,Jingyi LIU,Zhifang XU,Shuwen LIU,Yuan YANG,Yang CHEN,Yu LUO,Yinjie CUI. Research progress in changes of intestinal flora after spinal cord injury and their effects on spinal neuroinflammation[J].Journal of Jilin University(Medicine Edition), 2024, 50(6): 1751-1756.

References 34

1	IZZY S. Traumatic spinal cord injury［J］. Continuum， 2024， 30（1）： 53-72.
2	AGIRMAN G， YU K B， HSIAO E Y. Signaling inflammation across the gut-brain axis［J］. Science， 2021， 374（6571）： 1087-1092.
3	KIGERL K A， HALL J C E， WANG L L， et al. Gut dysbiosis impairs recovery after spinal cord injury［J］. J Exp Med， 2016， 213（12）： 2603-2620.
4	AHUJA C S， NORI S， TETREAULT L， et al. Traumatic spinal cord injury-repair and regeneration［J］. Neurosurgery， 2017， 80（3S）： S9-S22.
5	FILBIN M T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS［J］. Nat Rev Neurosci， 2003， 4： 703-713.
6	SQUAIR J W， DHALIWAL R， CRAGG J J， et al. National survey of bladder and gastrointestinal dysfunction in people with spinal cord injury［J］. J Neurotrauma， 2019， 36（12）： 2011-2019.
7	ZHANG C， ZHANG W， ZHANG J， et al. Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury［J］. J Transl Med， 2018， 16（1）： 353.
8	JING Y L， YU Y， BAI F， et al. Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model： involvement of brain-gut axis［J］. Microbiome， 2021， 9（1）： 59.
9	YU B B， QIU H D， CHENG S P， et al. Profile of gut microbiota in patients with traumatic thoracic spinal cord injury and its clinical implications： a case-control study in a rehabilitation setting［J］. Bioengineered， 2021， 12（1）： 4489-4499.
10	GUNGOR B， ADIGUZEL E， GURSEL I， et al. Intestinal microbiota in patients with spinal cord injury［J］. PLoS One， 2016， 11（1）： e0145878.
11	RICHARDSON P M， MCGUINNESS U M， AGUAYO A J. Axons from CNS neurons regenerate into PNS grafts［J］. Nature， 1980， 284（5753）： 264-265.
12	JING Y L， YANG D G， BAI F， et al. Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice［J］. J Neurotrauma， 2019， 36（18）： 2646-2664.
13	ZHAO J Y， BI W， XIAO S， et al. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice［J］. Sci Rep， 2019， 9（1）： 5790.
14	SINGH S， SAHU K， SINGH C， et al. Lipopolysaccharide induced altered signaling pathways in various neurological disorders［J］. Naunyn Schmiedebergs Arch Pharmacol， 2022， 395（3）： 285-294.
15	LEITNER G R， WENZEL T J， MARSHALL N， et al. Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders［J］. Expert Opin Ther Targets， 2019， 23（10）： 865-882.
16	MAZGAEEN L， GURUNG P. Recent advances in lipopolysaccharide recognition systems［J］. Int J Mol Sci， 2020， 21（2）： 379.
17	MYERS S A， GOBEJISHVILI L， SARASWAT OHRI S， et al. Following spinal cord injury， PDE4B drives an acute， local inflammatory response and a chronic， systemic response exacerbated by gut dysbiosis and endotoxemia［J］. Neurobiol Dis， 2019， 124： 353-363.
18	RONG Z J， HUANG Y L， CAI H H， et al. Gut microbiota disorders promote inflammation and aggravate spinal cord injury through the TLR4/MyD88 signaling pathway［J］. Front Nutr， 2021， 8： 702659.
19	REICHARDT N， DUNCAN S H， YOUNG P， et al. Phylogenetic distribution of three pathways for propionate production within the human gut microbiota［J］. ISME J， 2014， 8（6）： 1323-1335.
20	HOLOTA Y， DOVBYNCHUK T， KAJI I， et al. The long-term consequences of antibiotic therapy： role of colonic short-chain fatty acids （SCFA） system and intestinal barrier integrity［J］. PLoS One， 2019， 14（8）： e0220642.
21	DONG Y， CUI C. The role of short-chain fatty acids in central nervous system diseases［J］. Mol Cell Biochem， 2022， 477（11）： 2595-2607.
22	O’CONNOR G， JEFFREY E， MADORMA D， et al. Investigation of microbiota alterations and intestinal inflammation post-spinal cord injury in rat model［J］. J Neurotrauma， 2018， 35（18）： 2159-2166.
23	LANZA M， CAMPOLO M， CASILI G， et al. Sodium butyrate exerts neuroprotective effects in spinal cord injury［J］. Mol Neurobiol， 2019， 56（6）： 3937-3947.
24	CHEN S J， CHEN C C， LIAO H Y， et al. Association of fecal and plasma levels of short-chain fatty acids with gut microbiota and clinical severity in patients with parkinson disease［J］. Neurology， 2022， 98（8）： e848-e858.
25	YANO J M， YU K， DONALDSON G P， et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis［J］. Cell， 2015， 161（2）： 264-276.
26	REIGSTAD C S， SALMONSON C E， RAINEY J F， et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells［J］. FASEB J， 2015， 29（4）： 1395-1403.
27	CHENG J， LI W M， WANG Y， et al. Electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats［J］. Microb Biotechnol， 2022， 15（3）： 862-873.
28	PARK D H， PARK J Y， KANG K S， et al. Neuroprotective effect of gallocatechin gallate on glutamate-induced oxidative stress in hippocampal HT22 cells［J］. Molecules， 2021， 26（5）： 1387.
29	STRANDWITZ P. Neurotransmitter modulation by the gut microbiota［J］. Brain Res， 2018， 1693（Pt B）： 128-133.
30	DIEHL G E， LONGMAN R S， ZHANG J X， et al. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX（3）CR1（hi） cells［J］. Nature， 2013， 494（7435）： 116-120.
31	ESPÍRITO SANTO C CDO， SILVA FIORIN FDA， ILHA J， et al. Spinal cord injury by clip-compression induces anxiety and depression-like behaviours in female rats： the role of the inflammatory response［J］. Brain Behav Immun， 2019， 78： 91-104.
32	JING Y L， BAI F， YU Y. Spinal cord injury and gut microbiota： a review［J］. Life Sci， 2021， 266： 118865.
33	SINGH V， ROTH S， LLOVERA G， et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke［J］. J Neurosci， 2016， 36（28）： 7428-7440.
34	ESPINOSA-MEDINA I， SAHA O， BOISMOREAU F， et al. The sacral autonomic outflow is sympathetic［J］. Science， 2016， 354（6314）： 893-897.

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Research progress in changes of intestinal flora after spinal cord injury and their effects on spinal neuroinflammation

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