Journal of Jilin University Medicine Edition ›› 2015, Vol. 41 ›› Issue (04): 808-813.doi: 10.13481/j.1671-587x.20150427

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Analysis on association between polymorphism of apolipoprotein E genotypes and blood lipid levels in male population

FU Qianxi1, ZHOU Li1, TANG Min2, ZHANG Mingjun3, TANG Xiaojun1   

  1. 1. Department of Epidemiology, College of Public Health and Management, Chongqing Medical University, Chongqing 400016, China;
    2. College of Medical Examination, Chongqing Medical University, Chongqing 400016, China;
    3. Clinical Laboratory, Chongqing Jiulongpo First People's Hospital, Chongqing 400050, China
  • Received:2014-09-29 Published:2015-08-01

Abstract:

Objective To investigate the relationships between apolipoprotein E(APOE) genotypes and blood lipid levels in the male population,and to provide theoretical basis for the diagnosis of dyslipidemia indexes. Methods A cross-sectional health survey was carried out in three hospitals in Chongqing.The random samples came from 365 males in physical examination centers;among them 242 patients with high level of blood lipids were used as case group;and the other 114 healthy subjects were used as control group.The plasma levels of total cholesterol (TC),triglycerides(TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol(LDL-C) were determined;the heights and body weights were detected.The genotypes of APOE were evaluated by gene chip sequencing method. Results Six kinds of genotypes in the population were find,among them E3/3 had the highest frequency of APOE genotypes (69.10%),meanwhile the frequency of APOE E2 allele was 17.93%.The frequency of E3 was 75.84%,and the frequency of E4 was 6.18%.There were statistically significant differences of the TC levels between the patients with different APOE genotypes in case group (P<0.05),meanwhile the E4 carriers had a higher TC level than E2 and E3 carriers (P<0.05).The multiple linear regression analysis showed that APOE polymorphism was positively related with the levels of TC and TG(r=0.157,P<0.05;r=0.276,P<0.05),however it was negatively related with the HDL level(r=-0.153,P<0.05). Conclusion The polymorphism of APOE is related to the blood lipid levels in Chinese male population,while the patients with APOE4 genotype have higher TC and TG levels.

Key words: apolipoprotein E, genotype, body mass index, blood lipid

CLC Number: 

  • R589.2