Journal of Jilin University Medicine Edition ›› 2015, Vol. 41 ›› Issue (05): 1004-1007.doi: 10.13481/j.1671-587x.20150523

Previous Articles     Next Articles

Expressions of P21 and survivin proteins in glioma tissue and their clinical significances

DONG Zhiqiang, LI Qiang, HE Zhenhua, PAN Yawen   

  1. Department of Neurosurgery, Second Hospital, Lanzhou University, Lanhzou 730030, China
  • Received:2015-01-14 Published:2015-09-29

Abstract:

Objective To investigate the expressions of P21 and survivin proteins in human glioma tissue, and normal brain tissue, and to analyze their clinical significances. Methods According to the pathological standards formulated by the WHO in 2007,41 cases of glioma tissue samples were divided into 9 cases of grade Ⅰ,14 cases of gradeⅡ,10 cases of grade Ⅲ and 8 cases of grade Ⅳ;the other 12 cases of normal brain tissue were used as control group.The expressions of P21 and survivin proteins in human glioma tissue and normal brain tissue were examined with immunohistochemical method,and the relationship between them was analyzed. Results The positive expression rates of P21 and survivin proteins in normal brain tissue and glioma tissue were 91.7% and 53.7%,0% and 51.2%,and the differences between different tissues were statistically significant (P<0.05).The positive expression rates of P21 protein in the grade Ⅰ-Ⅱ and grade Ⅱ-Ⅲ glioma tissue were 69.6% and 33.3%,respectively,while the positive expression rates of survivin protein were 34.8% and 72.2%.The positive expression rate of P21 in the grade Ⅲ-Ⅳ glioma tissue was significantly lower than that in the grade Ⅰ-Ⅱglioma tissue, while the positive expression rate of survivin protein in the grade Ⅲ-Ⅳ glioma tissue was significantly higher than that in the grade Ⅰ-Ⅱ glioma tissue(P<0.05). Conclusion The loss of expression of P21 protein and the overexpression of survivin protein are associated with the malignant degree of gliomas.The P21 protein can inhibit the occurrence and development of glioma and the survivin protein can promote the development of glioma.

Key words: glioma, P21, survivin, immunohistochemistry

CLC Number: 

  • R739.41