LPL基因mRNA在精神分裂症模型大鼠脑组织中的表达

doi:10.13481/j.1671-587x.20160103

Abstract

Abstract:

Objective: To explore the expressions of lipoprotein lipase (LPL)gene mRNA in the prefrontal cortex,amygdale,caudate-putamen and hippocampus tissues of the model rats with schizophrenia,and to clarify the mechanism in the pathogeneses of schizophrenia.Methods: The rat modes with schizophrenia were made by administing phencyclidine(PCP)to the prenatal rats.24 model rats were used as model group,and another 21 Wistar rats were used as control group. The models were certified and the cognition changes were detected by Morris water maze test. The expression levels of LPL gene mRNA in the prefrontal cortex,amygdale,caudate-putamen and hippocampus tissues of the model rats with schizophrenia were tested by Real-Time PCR. Results: In Morris water maze test,the time of arriving at the platform of the rats in model group was 4.25 times longer compared with control group(P<0.01). The mRNA expression levels of LPL gene decreased in prefrontal cortex and hippocampus of the rats in model group were decreased by 61.7% and 89.0% compared with control group (P<0.05).Conclusion: The decreasing of LPL gene expression levels in the prefrontal cortex and hippocampus tissues of the model rats may be associated with the pathogenesis of schizophrenia,and it may be related to the cognition disorder.

Key words: lipoprotein lipase gene, schizophrenia, Real-Time PCR

CLC Number:

R-332

XING Hongyuan, ZHAO Jing, LIU Chunyan, LIU Yang, LIU Yang, WANG Zhenqi. Expression of LPL gene mRNA in brain tissue of model rats with schizophrenia[J].Journal of Jilin University Medicine Edition, 2016, 42(01): 11-14.

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Expression of LPL gene mRNA in brain tissue of model rats with schizophrenia

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