中药联合利培酮治疗精神分裂症有效性及安全性的Meta分析

doi:10.13481/j.1671-587x.20160424

Abstract

Abstract:

Objective: To approach the effectiveness and safety of traditional Chinese medicine combined with risperidone in the treatment of schizophrenia, and to provide basis for their application in clinic. Methods: The Cochrane, Pubmed, EMBase, CNKI, Wanfang and VIP databases were used to retrieve the randomized controlled trials (RCTs) and CCTs about traditional Chinese medicine combined with risperidone in the treatment of schizophrenia by computer;and manual retrieval was performed at the same time.The literatures met the standard were collected.The qualities of all the included studies were assessed by Cochrane Handbook and Meta-analysis was performed by use of the RevMan 5.2 software. Results: Fifteen trials and 1 314 patients were included in this review. The qualities of 11 studies were grade C.The Meta-analysis results showed that the clinical effective rate in traditional Chinese medicine combined with risperidone treatment group was higher than that in control group, the difference between two groups was statistically significant (OR=2.11, 95%CI:1.59-2.81, P < 0.01).The incidence of adverse drug reactions (insomnia, extrapyramidal symptoms, akathisia) in traditional Chinese medicine combined with risperidone treatment group was lower than that in alone risperidone group, and there were significant differences between two groups (OR=0.25,95%CI:0.17-0.36, P < 0.01). Conclusion: Traditional Chinese medicine combined with risperidone is superior to simple application of risperidone in the treatment of schizophrenia, and they can reduce the occurrence of adverse effects of medicine.

Key words: schizophrenia, traditional Chinese medicine, risperidone, Meta-analysis, systematic review

CLC Number:

R749.3

TAO Ruying, LI Miao, ZHANG Hui. Meta-analysis on effectiveness and safety of traditional Chinese medicine combined with risperidone in treatment of schizophrenia[J].Journal of Jilin University Medicine Edition, 2016, 42(04): 757-762.

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Meta-analysis on effectiveness and safety of traditional Chinese medicine combined with risperidone in treatment of schizophrenia

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