原发骨髓弥漫大B细胞淋巴瘤1例报告及文献复习

doi:10.13481/j.1671-587x.20160435

Abstract

Abstract:

Objective: To analyze the diagnosis and treatment of 1 case of primary bone marrow diffuse large B cell lymphoma (DLBCL), and to provide the reference for its dignosis and treatment. Methods: Combined the medical history and other auxiliary examination results, the possibility of diagnosis of primary bone marrow lymphoma(PBML) was suspected. Bone marrow biopsy and immunohistochemistry were carried out for diagnosis, and R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) was selected as the chemotherapy scheme. Results: The diagnostic basis of the case was in accordance with the diagnostic standard of PBML. According to the results of immunohistochemical staining, it was classified as the DLBCL subtype. Then the patient received 6 cycles of R-CHOP immune chemotherapy. Complete remission of bone marrow cell morphology was gained after the first cycle of R-CHOP treatment, and the patient was treated for another five cycles and the complete remission was retained in 3 months of follow up after drug withdrawal. Conclusion: Bone marrow biospy and immunohistochemistry have the unique diagnostic values for primary bone marrow DLBCL, and the regimens containing rituximab may provide a ideal efficacy during short term observation.

Key words: primary bone marrow lymphoma, diffuse large B cell lymphoma, bone marrow biopsy

CLC Number:

R733.4

ZHANG Wenlong, YANG Hua, SUN Yanxia. Primary bone marrow diffuse large B-cell lymphoma: One case report and literature review[J].Journal of Jilin University Medicine Edition, 2016, 42(04): 817-820.

References

[1] Kajiura D, Yamashita Y, Mori N. Diffuse large B-celllymphoma initially manifesting in the bone marrow [J]. Am J ClinPathol,2007,127(5):762-769.

[2] Chang H, Hung YS, Lin TL,et al. Primary bone marrowdiffuse large B cell lymphoma: a case series and review [J].Ann Hematol,2011,90(7):791-796.

[3] Martinez A, Ponzoni M, Agostinelli C, et al. Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-Hodgkin lymphomas [J]. Am J Surg Pathol,2012,36(2): 296-304.

[4] Alvares CL, Matutes E, Scully MA, et al. Isolated bone marrowinvolvement in diffuse large B cell lymphoma: a report of threecases with review of morphological,immunophenotypic andcytogenetic findings [J]. Leuk Lymphoma,2004,45(4):769-775.

[5] Kong SY, Cho EH, Woo HY, et al. De novo CD5 positive diffuse large B-cell lymphomas with bone marrow involvement in Korean [J]. J Korean Med Sci,2004,19(6):815-819.

[6] Strauchen JA. Primary bone marrow B-cell lymphoma:report of four cases[J]. Mt Sinai J Med,2003,70(2):133-138.

[7] Kagoya Y,Sahara N,Matsunaga T,et al. A case of primary bone marrow B-cell non Hodgkin's lymphoma with severe thrombocytopenia:case report and a review of the literature [J]. Indian J Hematol Blood Transfus,2010,26(3):106-108.

[8] 刘慧敏,易树华,刘恩彬,等。原发骨髓弥漫大B细胞淋巴瘤三例报告并文献复习 [J].中华血液学杂志,2014,35(10):914-917.

[9] Arber DA, George TI. Bone marrow biopsy involvement by non-Hodgkin's lymphoma: frequency of lymphoma types,patterns, blood involvement, and discordance with other sites in 450 specimens [J].Am J Surg Pathol,2005,29(12):1549-1557.

[10] Torlakovic E, Torlakovic G, Brunning RD. Follicular pattern of bone marrow involvement by follicular lymphoma [J]. Am J Clin Pathol,2002,118(5):780-786.

[11] Yamaguchi M, Seto M, Okamoto M, et al. De novo CD5⁺ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients [J]. Blood,2002,99(3):815-821.

[12] Merli M, Arcaini L, Boveri E,et al. Assessment of bone marrow involvement in non-Hodgkin's lymphomas: comparison between histology and flow cytometry [J].Eur J Haematol,2010,85(5):405-415.

[13] 张文龙,许人,白元松,等.以骨髓侵犯为唯一表现FCM检测阴性的淋巴瘤1例报道并文献复习 [J].中国实验诊断学,2012,16(6):1141-1142.

[14] Kazama H, Teramura M, Yoshinaga K,et al. Long-term remission of primary bone marrow diffuse large B-cell lymphoma treated with high-dose chemotherapy rescued by in vivo rituximab-purged autologous stem cells [J].Case Rep Med,2012,2012:957063.

Primary bone marrow diffuse large B-cell lymphoma: One case report and literature review

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 8

Metrics

Comments

Recommended 0

[1]	GAO Huan, BAI Yuansong, DAI Enyong, HAN Leng, LU Zhenxia, ZHAO Yanan. Recurrent or refractory childhood B cell lymphoblastic lymphoma: A case report and literature review [J]. Journal of Jilin University Medicine Edition, 2018, 44(02): 416-420.
[2]	LI Xiaoxia, SUN Yan, QU Rongfeng, REN Lishen, LI Yarong. Primary breast diffuse large B-cell lymphoma: A report of 3 cases and literature review [J]. Journal of Jilin University Medicine Edition, 2018, 44(01): 166-169.
[3]	QIN Beibei, LI Yaqing, LI Xiaoli, LU Lisha, ZHANG Xudong, ZHANG Mingzhi. Expressions of key molecules of Wnt/β-catenin signal pathway in NK/T-cell lymphoma tissue and their significances [J]. Journal of Jilin University Medicine Edition, 2015, 41(02): 230-234.
[4]	HU Yan-wei,ZHANG Ming-zhi,CAO Ling,ZHANG Xu-dong,LIU Qian-qian,HAN Li-juan，HU Teng-peng,YANG Li,WEN Jian-guo. Expression of Notch signal molecules in NK/T lymphoma cells and its significance [J]. Journal of Jilin University Medicine Edition, 2013, 39(4): 657-660.
[5]	. Application of core needle biopsy in diagnosis of malignant lymphoma [J]. J4, 2011, 37(2): 335-338.
[6]	LIU Shu-chun ,ZHAO Wen-ju ,LU Zhe,LI Yan-bo,KANG Shun-ai ,GONG Shou-liang. Dose-rate effect of adaptive response of apoptosis and cell cycle progression induced by low-dose ionizing radiation in EL-4 lymphoma cells in vitro [J]. J4, 2008, 34(1): 24-27.
[7]	ZHANG Fu-ming，LI Fan. Detection of EB virus in peripheral blood of patients withnasopharyngeal carcinoma by ramification amplification method [J]. J4, 2004, 30(1): 105-107.
[8]	LYU Pin, YIN Jinzhi, LIU Jing, SUN Yang, LIU Liying, REN Jin, MA Zhongsen. Fiberoptic bronchoscopic argon plasma coagulation and cryosurgery for tracheal mucosa associated lymphoid tissue lymphoma: A case report and literature review [J]. Journal of Jilin University Medicine Edition, 2016, 42(01): 152-154.