支气管哮喘患儿血清骨膜蛋白水平变化及其意义

doi:10.13481/j.1671-587x.20170120

Abstract

Abstract:

Objective: To explore the change of serum periostin level in peripheral blood of the children with bronchial asthma,and to clarify its role in asthma.Methods: Sixty-five children with bronchial asthma were randomly chosen as observation group,and 50 healthy children were also randomly chosen as control group.The levels of periostin,IgE,eosinophil cationic protein(ECP) and the number of eosinophils in peripheral blood of all subjects were detected by enzyme-linked immunosorbent assay (ELISA). The fractional exhaled nitric oxide (FeNO) levels and pulmonary function test indexes including forced expiratory volume in one second/predicted value ratio (FEV₁% pred),forced vital capacity (FVC) and FEV₁/FVC ratio were also detected.Results: Compared with control group,the serum periostin,IgE,and ECP levels,the number of eosinophils and FeNO in observation group were significantly increased (P<0.05),while the FEV₁%pred and FEV₁/FVC ratio were significantly decreased (P<0.05).The area under ROC curve (AUC) was 0.668 (P=0.02) and the threshold for periostin to identify asthma was 80.89 μg·L^-1 (95% CI:0.570-0.766) with the sensitivity of 29.23% and specificity of 92.00%. Periostin was positively correlated with the eosinophil count as well as FeNO (r=0.519, P=0.019;r=0.602,P=0.008).Conclusion: The periostin level in peripheral blood of the children with asthma is significantly increased and it can be used as a preliminary indicator to rule out asthma in the children.Inhibiting Th2-mediated inflammatory response is one target for the treatment of asthma.

Key words: bronchial asthma, airway hyperresponsiveness, enzyme-linked immunosorbent assay, periosteum protein

CLC Number:

R725.6

LI Yanfeng, WANG Hongbo, GAO Yang, ZHENG Yuxuan, LIU Li. Change of serum periostinlevel in children with bronchial asthma and significance[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 101-105.

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Change of serum periostinlevel in children with bronchial asthma and significance

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