Abstract: Objective: To study the influence of prophylactic bilateral salpingectomy during hysterectomy in ovarian function of the premenopausal women with benign uterine disease and its preventive effect on the pelvic diseases(malignant/benign pelvic lesions or pelvic inflammatory disease). Methods: A total of 100 patients with benign uterine disease underwent hysterectomy were collected and divided into two groups,including 50 patients underwent simultaneous hysterectomy and prophylactic bilateral salpingectomy (prevention group) and 50 patients underwent only hysterectomy (control group).The operative time,blood loss, evacuation time,and hospitalization time of the patients in two groups were detected; the antral follicle count, levels of serum estradiol(E2),follicle stimulating hormone(FSH) and luteinizing hormone(LH)) and the incidence of perimenopausal symptoms of the patients in two groups before operation and six months, 1 year after operation were compared; the incidence of pelvic disease of the patients after operation were compared. Results: The operative time,blood loss,evacuation time, and hospitalization time of the patients between two groups were not significantly different(P>0.05).Compared with before operation,the antral follicle count and the E2 levels of the patients 6 months and 1 year after operation in two groups were decreased, and the FSH and LH levels of the patients were increased (P<0.01).There were no significant differences in the levels of FSH,LH,E2 and the antral follicle count of the patients between two groups 6 months and 1 year after operation(P>0.05).The incidence of perimenopausal symptoms of the patients in two groups 6 months and 1 year after operation showed no significant difference(P>0.05).The incidence of ovarian malignant tumor and ovarian benign tumor of the patients in two groups 6 months and 1 year after operation had no significantly differences (P>0.05). The incidence of pelvic inflammatory disease of the patients in control group was higher than that in prevention group(P<0.05). There were 2 patients diagnosed as tubal carcinoma in control group 1 year after operation, and the pathological findings showed the atypical cells in 2 patients in prevention group. Conclusion: Prophylactic bilateral salpingectomy during hysterectomy does not damage the ovarian function and can reduce the incidence of pelvic malignant/benign tumor and pelvic inflammatory disease.

Key words: ovarian neoplasms, perimenopause, ovarian function failure, prophylactic bilateral salpingectomy