Abstract: Objective: To investigate the effects of gender,age,and blood lipid levels on the incidence of colorectal polyps,and to clarify the risk factors of colorectal polyps,and to provide the reference for clinical diagnosis and treatment of colorectal polyps. Methods: The serum lipid levels of the patients with colorectal polyps (polyps group,n=239) and the healthy controls or the patients with chronic nonspecific enteritis (control group,n=245) were examined.The effects of gender, age and blood lipid level on the incidence of colorectal polyps were analyzed,and the levels of blood lipids of the colorectal polyps patients with different pathogenesis parts and pathological types were detected and compared. Results: The incidence of colorectal polyps of the patients with high level of low density lipoprotein cholesterol(LDL-C) (P<0.01,OR=6.26,95%CI:3.79-10.33) and high level of triglyceride(TG)(P=0.043,OR=1.63,95%CI:1.02-2.63) and male (P=0.001,OR=2.05,95%CI:1.35-3.11) and the patients whose ages were older than 66 years old were increased. There were no significant differences in the levels of high density lipoprotein cholesterol(HDL-C) and total cholesterol (TC) of the patients between two groups (P>0.05).The levels of LDL-C(t=-4.497,P<0.01),TG (t=-2.116,P=0.036),TC (t=-3.843,P<0.01) and ratio of hyperlipidaemia(HLP) (χ²=9.458,P=0.002)in the patients with left colorectal polyps were higher than those in the patients with right colorectal polyps;but there were no significant differences in the gender,age and HDL-C level of the patients in these two groups (P>0.05).The level of LDL-C of the patients with non-adenomatous colorectal polyps was higher than that of the patients with adenomatous colorectal polyps (t=2.049,P=0.042);but there were no statistically significances in the gender,age and HDL-C level,TG level,TC level, and HLP ratio of the patients between two groups(P>0.05). Conclusion: Male,older,high levels of LDL-C and TG are the independent risk factors for colorectal polyps.High level of LDL-C is associated with non-adenomatous colorectal polyps.

Key words: low density lipoprotein, colorectal polyps, high density lipoprotein, total cholesterol, hyperlipidaemia, triglycerides