Abstract: Objective:To evaluate the efficacy and safety of oxycodone combined with dexmedetomidine in the postoperative analgesia in the patients underwent laparoscopic radical surgery of colon cancer. Methods:Sixty colon cancer patients underwent laparoscopic radical surgery and recevied patient-controlled intravenous analgesia after operation were randomly divided into control group and experiment group(n=30) using The "Envelope Method".The patients in control group were given 0.5 mg·kg^-1 oxycodone, and the patients in experiment group were given 0.5 mg·kg^-1 oxycodone and 2 μg·kg^-1 dexmedetomidine. The parameters of analgesic pump in two groups were set as follows:the continuous perfusion rate was 1 mL·h^-1,the single bolus was 1.5 mL, the lock-out time was 10 min,and the total volume was 100 mL. The VAS scores of pain at rest and activity pain of the patients in two groups were evaluated at exiting the post anesthesia care unit (T₁), and at 6 h (T₂), 12 h (T₃), 24 h (T₄) and 48 h (T₅) after operation. The dose of analgesic drugs used, times of emergent rescue analgesia and anus exhaust time after operation of the patients in two groups were recorded; the postoperative adverse responses,vital signs and Ramsay scores of the patients in two groups were observed. Results:The VAS scores of activity pain at T₂-T₅ and pain at rest at T₂-T₄ of the patients in experiment group(P_T2-T5=0.000;P_T2=0.018,P_T3=0.001,P_T4=0.010) were lower than those in control group;the doses of analgesic drugs used and times of emergent rescue analgesia of the patients in experiment group were significantly lower than those in control group(P=0.000,P=0.029);the anus exhaust time after operation was significantly earlier than that in control group(P=0.030);the cases of nausea of the patients in experiment group were significantly lower than that in control group(P=0.023),and there were no significantly differences in the other various adverse effects of the patients between two groups(P>0.05). Conclusion:Oxycodone combined with dexmedetomidine is effective and safe for the postoperative analgesia after laparoscopic radical surgery of colon cancer.

Key words: postoperative analgesia, dexmedetomidine, colon neoplasms, oxycodone