IL-4-33C/T和IL-6-572C/G基因多态性与慢性阻塞性肺疾病易感性的关联性分析

doi:10.13481/j.1671-587x.20150128

Abstract

Abstract:

Objective To investigate the association between the single nucleotide polymorphisms (SNPs) of interleukin 4 (IL-4) promoter region gene-33C/T(IL-4-33C/T), interleukin-6 (IL-6) promoter region gene-572C/G(IL-6-572C/G) and the susceptibility of chronic obstructive pulmonary disease (COPD), and to provide theoretical basis for genetic mechanism of COPD. Methods A case-control study was used in this research.100 cases of COPD were selected as case group, and 100 healthy people matched in age and sex were selected as control group.PCR-RELP analysis was employed to detect the genotypes of the subjects in two groups, and statistical analysis software SPSS19.0 was used to analyze the association between IL-4 -33C/T, IL-6 -572C/G and susceptibility of COPD. Results The distribution of genotypic frequencies of IL-4 -33C/T and IL-6 -572C/G sites didn't deviate from Hardy-Weinberg equilibrium in both case group and control group(P>0.05).The distribution of genotypic and allelic frequencies at IL-4 -33C/T site showed no statistical significance between case group and control group(P>0.05).The distribution of genotypic and allelic frequencies at IL-6 -572C/G site showed statistical significance between case group and control group(χ²=17.398, P<0.001;χ²=23.169, P<0.001). Conclusion The polymorphism of IL-4-33C/T site may be not associated with the susceptibility of COPD.The polymorphism of IL-6-572C/G site may be associated with the susceptibility of COPD.

Key words: chronic obstructive pulmonary disease, interleukin-4, interleukin-6, gene polymorphism

CLC Number:

R563.9

ZHANG Wenjing, JING Hongyu, XU Hongbang, QIAN Donghua. Analysis on association between polymorphisms of IL-4-33C/T and IL-6-572C/G and susceptibility of chronic obstructive pulmonary disease[J].Journal of Jilin University Medicine Edition, 2015, 41(01): 145-149.

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Analysis on association between polymorphisms of IL-4-33C/T and IL-6-572C/G and susceptibility of chronic obstructive pulmonary disease

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