Abstract: Objective: To investigate the efficacy of local application of methimazole cream in the patients with hyperthyroidism complicated with liver failure, and to provide reference for its clinical treatment.Methods: Two patients were admitted to hospital with jaundice as the main performance. Liver function and coagulation function supported the diagnosis of liver failure. The thyroid function indicators suggested hyperthyroidism. Combined with other related examination results, liver failure, hyperthyroidism and hepatitis B virus were diagnosed,and the local treatment of methimazole cream and other related treatments were given.Results: After treatment, the liver function of two patients returned to normal and the thyroid function was improved. After follow-up, one patient changed the external use of methimazole cream to oral treatment,and another patient was still treated in a local manner.Conclusion: There is a conflict in the treatment of hyperthyroidism complicated with liver failure. The local application of methimazole cream in the topic of reducing the risk of liver damage caused by drugs has good results in the treatment of hyperthyroidism. This method also provides the new ideas for its clinical treatment.

Key words: methimazole cream, hyperthyroidism, liver failure, case repot