喉部小细胞神经内分泌癌患者长期无病生存1例报告及文献复习

doi:10.13481/j.1671-587x.20190233

Abstract

Abstract: Objective: To analyze the clinical characteristics of patient with laryngeal small cell neuroendocrine carcinoma(LSCNC) with long-term disease-free survival,and to provide the basis for the diagnosis and treatment of LSCNC.Methods: The clinical materials of a patient with primary LSCNC were collected,and the clinical features,diagnosis and treatment of LSCNC and extrapulmonary small cell cancer (EPSCC) combined with the relative literatures were analyzed.Results: The patient was a 55-year-old man who had a long history of heavy smoking and drinking, and presented with neck mass.The laryngoscope revealed the uneven mass on the left side of epiglottic laryngeal surface.The subsequent biopsy of the neck mass indicated lymph node metastasis.The patient underwent laryngectomy and bilateral cervical lymph node dissection.The postoperative pathology indicated LSCNC; the immunohistochemistry results showed CD56(NK-1)(+), CK-pan(+), CgA(-), Syn(-)and Ki-67(+90%).The patient underwent radiotherapy to the tumor bed and lymph node drainage area and 6 courses of chemotherapy with EP regimen.No prophylactic cranial irradiation (PCI) was conducted.Regular follow-up with laryngoscope, crainial MRI and other examinations showed no recurrence and metastasis.The patient still alive with disease-free survival of 38 months now.Conclusion: LSCNC is highly malignant.The diagnosis mainly depends on the pathohistomorphology and immunohistochemistry examination.The combination of surgery, chemotherapy and radiotherapy is commonly used for LSCNC at present.PCI is not recommended routinely.Multimodality treatment can improve the prognosis.

Key words: laryngeal tumor, small cell neuroendocrine carcinoma, radiotherapy, chemotherapy, extrapulmonary small cell cancer

CLC Number:

R739.65

ZHU Xiaopeng, LIU Bailong, GUO Liang, LIU Hui, LI Cheng, LIU Min, DONG Lihua. Long-term disease-free survival in patient with laryngeal small cell neuroendocrine carcinoma: A case report and literature review[J].Journal of Jilin University(Medicine Edition), 2019, 45(02): 405-409.

References

[1] RENNER G. Small cell carcinoma of the head and neck:A review[J].Semin Oncol,2007,34(1):3-14.
[2] FERLITO A, DEVANEY K O, RINALDO A.Neuroendocrine neoplasms of the larynx:advances in identification, understanding, and management[J].Oral Oncol, 2006, 42(8):770-788.
[3] IQBAL M S, PALERI V, MOOR J, et al.Small cell neuroendocrine carcinoma of larynx:case series and literature review[J].J Laryngol Otol, 2015, 129(9):910-915.
[4] HALMOS G B, VAN DER LAAN T P, VAN HEMEL B M, et al.Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?[J].Eur Arch Otorhinolaryngol, 2013, 270(2):719-725.
[5] GNEPP D R.Small cell neuroendocrine carcinoma of the larynx.A critical review of the literature[J].ORL J Otorhinolaryngol Relat Spec, 1991, 53(4):210-219.
[6] FERLITO A, RINALDO A.Primary and secondary small cell neuroendocrine carcinoma of the larynx:a review[J].Head Neck, 2008, 30(4):518-524.
[7] POINTER K B, KO H C, BROWER J V, et al.Small cell carcinoma of the head and neck:An analysis of the National Cancer Database[J].Oral Oncol, 2017, 69:92-98.
[8] VAN DER LAAN T P, PLAAT B E, VAN DER LAAN B F, et al.Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx:A meta-analysis of 436 reported cases[J].Head Neck, 2015, 37(5):707-715.
[9] SONE M, UCHIDA I, TOMINAGA M, et al.Small cell carcinoma of the larynx treated with irinotecan and cisplatin[J].Auris Nasus Larynx, 2006, 33(2):223-225.
[10] LEE J M, LEE K B, NAM J H, et al.Prognostic factors in FIGO stage IB-ⅡA small cell neuroendocrine carcinoma of the uterine cervix treated surgically:results of a multi-center retrospective Korean study[J].Ann Oncol, 2008, 19(2):321-326.
[11] BARKER J L Jr, GLISSON B S, GARDEN A S, et al.Management of nonsinonasal neuroendocrine carcinomas of the head and neck[J].Cancer, 2003, 98(11):2322-2328.
[12] CICIN I, KARAGOL H, UZUNOGLU S, et al.Extrapulmonary small-cell carcinoma compared with small-cell lung carcinoma:A retrospective single-center study[J].Cancer, 2007, 110(5):1068-1076.
[13] BRENNAN S M, GREGORY D L, STILLIE A, et al.Should extrapulmonary small cell cancer be managed like small cell lung cancer?[J].Cancer, 2010, 116(4):888-895.
[14] GALANIS E, FRYTAK S, LLOYD R V.Extrapulmonary small cell carcinoma[J].Cancer, 1997, 79(9):1729-1736.
[15] YAZICI O, OZDEMIR N Y, SENDUR M A, et al.Current approaches for prophylactic cranial irradiation in extrapulmonary small cell carcinoma[J].Curr Med Res Opin, 2014, 30(7):1327-1336.
[16] TREMONT-LUKATS I W, BOBUSTUC G, LAGOS G K, et al.Brain metastasis from prostate carcinoma:The M.D.Anderson Cancer Center experience[J].Cancer, 2003, 98(2):363-368.
[17] PAPANDREOU C N, DALIANI D D, THALL P F, et al.Results of a phase Ⅱ study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate[J].J Clin Oncol, 2002, 20(14):3072-3080.
[18] ROSENTHAL D I, BARKER J L Jr, EI-NAGGAR A K, et al.Sinonasal malignancies with neuroendocrine differentiation:patterns of failure according to histologic phenotype[J].Cancer, 2004, 101(11):2567-2573.
[19] SALHAB M, MIGDADY Y, DONAHUE M, et al.Immunohistochemical expression and prognostic value of PD-L1 in Extrapulmonary small cell carcinoma:a single institution experience[J].J Immunother Cancer, 2018, 6(1):42.
[20] HUSNAIN M, PARK W, RAMOS J C, et al.Complete response to ipilimumab and nivolumab therapy in a patient with extensive extrapulmonary high-grade small cell carcinoma of the pancreas and HIV infection[J].J Immunother Cancer, 2018, 6(1):66.

Long-term disease-free survival in patient with laryngeal small cell neuroendocrine carcinoma: A case report and literature review

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