Abstract: Objective:To study the therapeutic effect of compound Chinese medicine preparation of wild chrysanthemum and rhizoma drynariae combined with ornidazole in the treatment of chronic periodontitis,to explore the curative effect of this method in the treatment of chronic periodontitis,and to calarify its mechanism. Methods:A total of 112 patients with chronic periodontitis were divided into control group, ornidazole group, Chinese medicine group, Chinese medicine combined with ornidazole group (combination group) according the order of clinic time;there were 28 cases in each group. After basic periodontal treatment of the affected tooth(supragingival scaling and subgingival scaling), the periodontal pockets of the patients in control group were washed with 3%H₂O₂ and 0.9%NaCl injection by turns,once a week; the patients in ornidazole group were orally administered with ornidazole one piece at a time, twice a day;the patients in Chinese medicine group were injected with compound Chinese medicine preparation of wild chrysanthemum and rhizoma drynariae into the pocket to make the medicine overflow to the edge of the gingival margin,once a week; the patients in combination group were injected with compound Chinese medicine preparation into the periodontal pocket while orally administered with ornidazole. All patients in various groups were treated for 4 weeks.The periodontal indexes including modified plaque index(mPLI), modified sulcus bleeding index (mSBI),probing depth(PD), and attachment loss (AL) of the patients in various groups were observed before and after treatment; and the levels of tumor necrosis factor-α(TNF-α) and prostaglandin E₂ (PGE₂) in the gingival crevicular fluid (PISF) of the patients in various groups were detected after one course of treatment. Results:There were no significant differences in the periodontal indexes and the levels of TNF-αand PGE₂ in PISF of the patients before treatment between various groups(P>0.05).Compared with control group,the level of PGE₂ in PISF in Chinese medicine group was reduced(P<0.05);the PD and the PGE₂ level in PISF of the patients in ornidazole group were significantly reduced (P<0.05);the mPLI,mSBI,PD and AL, the levels of TNF-α and PGE₂ in PISF of the patients in combination group were significantly reduced (P<0.05).Compared with ornidazole group, there were no significant differences in the above indicators of the patients in Chinese medicine group (P>0.05);the mPLI, mSBI, PD and AL,the TNF-α level in PISF of the patients in combination group were significantly reduced (P<0.05).Compared with Chinese medicine group,the mPLI, mSBI, PD and AL,the levels of TNF-α and PGE₂ in PISF of the patients in combination group were significantly reduced(P<0.05). Conclusion:The traditional compound Chinese medicine preparation of wild chrysanthemum and rhizoma drynariae combined with ornidazole has the best therapeutic effect in the chronic periodontitis,which can improve the periodontal index and reduce the levels of TNF-α and PGE₂ in PISF of the patients.

Key words: chronic periodontitis, wild chrysanthemum, rhizome drynariae, ornidazole