细丝蛋白A在宫颈癌患者癌组织中的表达及其临床意义

doi:10.13481/j.1671-587x.20190608

Abstract

Abstract: Objective: To investigate the expression of filamin A (FLNa) in cervical cancer tissue and its relationships with the clinicopathological characteristics of the cervical cancer patients, to analyze the correlations between the expression of FLNa and the prognostic indicators, to clarify the feasibility of FLNa as a prognostic indicator for cervical cancer,and to provide the evidence for early clinical evaluation on the prognosis of cervical cancer. Methods: The positive expression rates of FLNa in 55 cases of cervical cancer tissue and adjacent tissue were detected by immunohistochemical method,the expression levels of FLNa mRNA in 20 cases of cervical cancer and adjacent tissues were detected by RT-PCR method, and the relationships between the expression of FLNa and the clinicopathological parameters of the patients with cervical cancer were analyzed. Results: The immunohistochemical results showed that FLNa was localized in the cytoplasm,the positive expression rate of FLNa in the basal cells was high and it expressed partly in the interstitium.FLNa highly expressed in the cervical cancer tissue and did not express in the adjacent normal tissue.The positive expression rate of FLNa in the patients with stage Ⅰ+Ⅱ cervical cancer was lower than that in the patients with stage Ⅲ+Ⅳ cervical cancer (P<0.05).The expression of FLNa in cancer tissue of the patients with cervical cancer was associated with TNM stage,lymph node metastasis and parametrial invasion (P<0.05).The RT-PCR results showed that the expression level of FLNa in 20 cases of cervical cancer tissue was higher than that in adjacent normal tissue (P<0.05). Conclusion: FLNa may become a indicator of evaluation on the prognosis of the patients with cervical cancer.

Key words: cervical cancer, filamin A, prognosis, immunohistochemistry

CLC Number:

R737.33

LIU Xiuhua, WANG Man, DONG Xinjie, LIU Jingnan, HAN Wei, GUAN Yinghui. Expression of filamin A in cancer tissue of cervical cancer patients and its clinical significance[J].Journal of Jilin University(Medicine Edition), 2019, 45(06): 1238-1242.

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Expression of filamin A in cancer tissue of cervical cancer patients and its clinical significance

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