Journal of Jilin University Medicine Edition ›› 2013, Vol. 39 ›› Issue (1): 122-127.doi: 10.7694/jldxyxb20130128

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Efficacy and influencing factor analysis of GP regimen
 in postoperative adjuvant chemotherapy for
 non-small-cell lung cancer


LI En-xi,YIN Wei-min,WANG Xu,MA Ke-wei   

  1. Tumor Center,First Hospital,Jilin University,Changchun 130021,
    China
  • Received:2012-08-13 Online:2013-01-28 Published:2013-01-30

Abstract: Objective  To observe the short-term efficacy of GP regimen in adjuvant chemotherapy in patients with non-small-cell lung cancer,and to study t
he factors influencing efficacy and analyze the adverse reactions.
Methods  Clinical data of 68 NSCLC patients received postoperative adjuvant chemotherapy of GP regimen was  retrospectively analyzed.Kaplan-Meier method was used to draw the disease-free survival curve.Log-rank time series analysis was used between different subgroups;C
OX proportional hazards model was used for the univariate and multivariate analyses.
Results  Of all the 68 cases,the median recurrence-free survival time was 33.7 months,56 cases were followed up more than one year,and one year disease-free survival rate was 83.9%;25 cases were followed up more than two years,and
two-year disease-free survival was 72.0%.Univariate analysis suggested that clinical stage(P<0.05),pathological type(P<0.05),degree of differentiation(P<0.05) significantly influenced the short-term efficacy. Multivariate analysis suggested that clinical stage(P<0.05),degree of differentiation(P<0.05) were thei
ndependent factors of the short-term efficacy.The major adverse reactions were stage 3 to 4 myelo-suppression including neutropenia(33.9%),granulocytopenia(20.6%),anemia(4.4%),and thrombocytopenia(4.4%),and  stage 3 to 4 nausea and vomiting(10.3%).
Conclusion The GP regimen is feasible,well-tolerated with a high disease control rate in one or two years in the adjuvant chemotherapy;clinical stage
and degree of differentiation are the independent factors of the short-term efficacy.

Key words: cancer,non-small cell lung, antineoplastic combined chemotherapy protocols, gemcitabine, cisplatin, median recurrence-freesurvival time, disease-free survival rate

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