Abstract: Objective To observe the action of Agaricus blazei Murrill ω-6 polyunsaturated fatty acid (ω-6APFA) on inhibiting the formation of thrombus and relieving arteriosclerosis. Methods Sixty rats were randomly divided into control group, natural soybean phospholipids capsule (NSPC) 0.70 g•kg^-1 •d^-1 group,ω-6APFA 0.07, 0.14 and 0.28 g•kg^-1•d^-1 groups (n=12). Rats in each group were exhibited once a day for 7 d,1 h after the last exhibition ,all rats were injected chloral hydrate 300 mg•kg^-1 in abdominal cavity to anesthetize, the carotid of the right neck was separated, and the time of thrombosis formation was determined by experimental intracorporeal thrombosis surveyor. Another 60 mice were randomly divided into control group, NSPC 1.0 g•kg^-1•d^-1group,ω-6APFA 0.1, 0.2 and 0.4 g•kg^-1•d^-1 groups (n=12). Mice were exhibited once a day for 7 d continuously, 1 h after the last exhibition, blood was extracted in the orbit vein, the clotting time was determined through glass slides method. Results NSPC 0.70 g•kg^-1• d^-1 and ω-6APFA 0.14，0.28 g•kg^-1•d^-1 had obvious inhibitory effect on thrombusformation in blood stasis rats, compared with model group(P＜0.05);andω-6APFA 0.14 and 0.28 g•kg^-1•d^-1 were superior to NSPC 0.70 g•kg^-1•d^-1. NSPC 1.0 g•kg^-1• d^-1 and ω-6APFA 0.2,0.4 g•kg^-1•d^-1 all could prolong the clotting time, compared with model group(P<0.05 or P<0.01),andω-6APFA　0.2, 0.4　g•kg^-1 •d^-1 were superior to NSPC 1.0 g•kg^-1 •d^-1. Conclusion ω-6APFA has the functions of inhibiting thrombusformation, promoting blood flow ability and lowering blood viscosity.

Key words: fatty acids , Omega-6, thrombosis, therapy