Abstract: Objective: To evaluate the clinical efficacy of thermal-therapy combined with ¹²⁵I radioactive particles by comparing the results of preoperative and postoperative images,serum carcino-embryonic antigen(CEA) and following-up after treatment of the patients with recurrent rectal cancer. Methods: Nineteen rectal cancer patients with postoperative recurrence after radiotherapy were treated with ¹²⁵I implantation guided by CT (20 cases were treated with operation, but 1 patient was exited who couldn't tolerate the thermal-therapy). Radioactive particle treatment planning system (TPS) was used to make the plan before the particle implantation, and the distance of the particle was 1.0 cm; all patients received CT scanning and were quantificationally evaluatated after implantation; the number of seeded particles was about 12-58, the radioactivity of the ¹²⁵I particle was 0.5 mCi, and the matching dose surrounding the tumor was 90-140 Gy. All patients were treated with microwave thermal-therapy after particle implantation, 60 min per time, lasting the temprature at 43℃, twice per week, for three weeks. And the patients were followed up after treatment for 3 months, the efficacy was evaluated by image and CEA results, and the urinary frequency, dysuria, hematuria and rectal bleeding were evaluated. Results: Compred with before treatment, after following up for 6 months, the image results showed that the tumor volume was reduced, and the blood CEA level of all patients were decreased from (30.25±8.32)mg·L^-1 to (11.89±5.22) mg·L^-1 (t=13.158,P<0.01);the local efficacy was 94.7% (18/19),and the pain relief rate was 94.4% (17/18);the NRS median was 6(4,7)before treatment,and it was 1(0,3) after treatment, there was significant difference (P<0.001).There were no frequent urination, urinary pain, hematuria, rectal bleeding and other complications in all patients. Conclusion: Thermal-therapy combined with ¹²⁵I radioactive particle implantation has good curative effects on the recurrent rectum cancer, and is effective means for recurrent rectum cancer treatment.

Key words: rectal neoplasma, thermal-therapy, ¹²⁵I radioactive particles, recurrence