Abstract: Objective To investigate the association between angiotensin Ⅱ type 1 receptor (AT₁R) gene polymorphism and hypertensive disorder complicating pregnancy （HDCP）. Methods Eighty-six pregnant women with HDCP and 74 normal pregnant women (control group) were recruited. Gene polymorphism of AT₁R at (-535)was detected with PCR-based restriction fragment length polymorphism(RFLP)method. Results ① The frequencies of CC,CT,TT genotypes of AT₁R at (-535) were 74.4%,20.9%,4.7% in HDCP group and 87.8%,8.1%,4.1% in control group,respectively;there was no significant difference berween two group（P>0.05）.The frequencies of the two alleles C, T were 84.9%,15.1% in HDCP group and 91.9%,8.1%in control group,respectively;there was no significant difference between two group （P>0.05）;②The distribution frequencies of AT₁R at(-535) in HDCP group in gestational hypertension,mild preeclampsia,severe preeclampsia(5.9%,7.1%,15.2%)were lower than that in eclampsia in HDCP group（P<0.05）.Conclusion The AT₁R (-535) C→T gene polymorphism is not associated with the pathogenesis of HDCP, but it has an association with the severity of HDCP.

Key words: pregnancy complication,cardiovascular, angiotension receptors,angiotension;polymorphism(genetics);gene