Abstract: Abstract:ObjectiveTo study the geneticrelationship between the isolated Keriyan population and ethnics in Xinjiang. Methods Three autosomal shorttandemrepeat (STR) polymorphisms (D5S818, D7S820 and D13S317) were analyzed by Genescan software in the isolated population in the center of Taklamakan desert of Xinjiang. Sheriver’s Dsw of the isolated population with others were estimated, and phylogenetic tree was constructed by using NeighborJoining method based on Dsw. Results Allelic frequencies of three autosomal STR were calculated, and the genetic distance based on allelic frequencies showed that the isolated population had the closest genetic distant with Uzbek of Xinjiang. ConclusionThe isolated population has the closest relationship with Uzbek, and they may be derived from the same ancestor.

Key words: STR, polymorphism, phylogenetic tree