Abstract:

Objective To study the relationship between matrixmetalloproteinase-9(MMP-9) C-1562T gene polymorphism  and the clinical manifestations  in patients with IgA nephropathy.Methods The polymorphism of MMP-9 C-1562T gene in  85 IgA nephropathy  patients were detected with polymerase chain reation-restriction fragment length polymorphism(PCR-RELP),SPSS13.0 was used to  analyze the correlations between the gene polymorphism  and  pre-infection,gross hematuria,renal area pain,hypertension,renal fuction change,confirmed to clinical features of nephritic syndrome or not and the degree of microscopic hematuria.Results The genetypic frequency distributions of MMP-9 C-1562T gene in  IgA nephropathy patients  were CC 65(72.94%),CT 23(27.06%),TT 0(0%),they were not deviated from Hardy-Weinbery equilibrium. The genotypes of IgA  may be associated with urinary  protein(U=502.0,P=0.0454),unassociated with pre-infection,gross hematuria,renal area pain,hypertension,renal fuction change,confirmed to clinical features of nephritic syndrome or not and the degree of microscopic hematuria（P>0.05）.Conclusion On clinical,MMP-9 C-1562T genotype of IgA nephropathy patients may impact on the degree of urinary protein,but not other clinical manifestations,and  prognosis of IgA nephropathy.

Key words: matrixmetalloproteinase-9;C-1562T gene;genetic polymorphism;IgA nephropathy;clinical manifestation