Abstract:

Abstract:Objective To investigate the distribution of human papillomavirus (HPV) genotypes between Yanbian area of China and South Korea.Methods 339 cases of uterine cervical cancer and its precursors were selected from Dept.of Pathology,Korea University Medical Center.Meanwhile,296 cases of uterine cervical cancer and its precursors,cervical intraepithelial neoplasia (CIN) were selected from Dept.of Pathology,Yanbian University Hospital and Yanbian Women’s Hospital.All of these cases were stained by HE,and appropriated blocks were selected for DNA extraction.And HPV genotypes were performed by oligonucleotide microarray (DNA chip).Results In Yanbian area of China,the positive rates of high-risk HPV were 32.6% in CIN-1,52.6% in CIN-2,54.7% in CIN-3,94.0% in squamous cell carcinoma(SCC),66.7% in cervical glandular intraepithelial neoplasm (CGIN)and 85.2% in adenocarcinoma. In South Korea,the positive rates of high-risk HPV were 34.6% in CIN-1,54.1% in CIN-2,63.2% in CIN-3,95.3% in SCC,66.7% in CGIN and 87.1% in adenocarcinoma.There was no significant difference between Yanbian of China and South Korea.HPV16 was the most common type in SCC,and HPV18 was followed.However,both HPV18 and 16 were the main types in cervical adenocarcinoma,and the positive rate of HPV18 was slightly higher than that of  HPV16.The multi-types of HPV infection cases were found in South Korea compared with  Yanbian area of China,such as the mixed infection of HPV16,18,31,33,52,58,66 and so on.The positive rates of multi-types HPV infection were 9.1% in CIN-2,16.7% in CIN-3,14.9% in SCC and 14.8% in adenocarcinoma in South Korea.Conclusion  HPV16 is the most common type in SCC of the cervix in both Yanbian area of China and South Korea,however both HPV18 and 16 are main types in adenocarcinoma of the cervix,in which the infection rate of HPV18 is slightly higher that of  than HPV16. Meanwhile,the cases of multi-types HPV infection are more frequently observed in South Korea than in Yanbian area of China.

Key words: human papillomavirus ；uterine cervical neoplasms;comparative study