Abstract:

Abstract:Objective To study the expressions of TGF-β and P53 protein in prostatic carcinoma tissue and their clinical significances.Methods Immunohistochemical method was used to detect the expressions of TGF-β and P53 protein in 36 cases of prostatic carcinoma.Results 36 cases of prostatic carcinoma included 10 cases of well differentiation,16 cases of moderate differentiation,10 cases of poor differentiation.The positive expression rates of TGF-β in well,moderately,poorly differented prostatic carcinoma tissues were 30%(3/10),37.5%(6/16),and 70%(7/10);the positive expression rates of P53 protein in well,moderately,poorly differented prostatic carcinoma tissues were 20%(2/10),25%(4/16),and 50%(5/10). The expression rates of TGF-β and P53 protein in well and moderately differented prostatic carcinoma tissues were lower than those in poorly differented prostatic carcinoma tissues(P<0.05).Conclusion The expressions of TGF-β and P53 have a negative correlation with the differented degree of prostatic carcinoma and the expressions of TGF-β and P53 may help to judge the pathologic grade and predict the prognosis of prostatic carcinoma.

Key words: prostatic neoplasms；transforming growth factor-β；P53 protein；immunohistochemistry