Abstract:

Abstract:Objective To investigate the association between MBD3 gene polymorphism and schizophrenia and provide theoretical basis for its etiological study. Methods The method of PCR-based ligase detection reaction (PCR-LDR) was applied to　detect the genotypes of the tag SNP on MBD3 gene in 50 family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. Hardy-Weinberg equilibrium for genotypic distribution was estimated by the goodness-of-fit χ test. The frequencies of genotype and allele of rs4807934 and rs4807122 locus of MBD3 gene were statistically computed. Results The distribution of genotypic frequency of rs4807934 and rs4807122 did not deviate from  Hardy-Weinberg equilibrium either in the patient group or in the parent group（P>0.05）.The haplotype relative risk test (HRR) showed there was no significant difference of frequency distribution of allele of rs4807934 and rs4807122 between patient group and parent group (P>0.05).The transmission disquilibrium test (TDT) showed the allele of rs4807934 and rs4807122 transmitted from heterozygotic parents to affected offsprings did not bias from 50 % (P>0.05) Conclusion The polymorphism of rs4807934 and rs4807112 of MBD3 gene may be not involved in the cause of schizophrenia in North Chinese Han population.

Key words:  MBD3, schizophrenia, tag SNP