Abstract:

Abstract:Objective To explore the effect of captopril  orally  administered for long term on learning and memory function of normal mice in order to provide  experiment base for clinical application of captopril.Methods Normal adult mice were divided control group and captopril group.The mice were administered with captopril （11.08—14.92　mg?kg-1?d-1）　for 12 weeks. The effect of captopri on learning and memory was detected with Morris water maze,Avoiding dark,Step-down and  cholinergic system (Ach content,AchE activity).Results Compared with control group.the latency,distance,average speed and starting angle of mice treated with captopril did not change significantly  from the first day to the fourth day;the time in platform，time in platform quadrant，times passing platform ，distance in platform/total distance×100%,starting angle,and average speed also did not change significantly in the fifth day in  Morris water maze （P>0.05）;the error times and the latency of mice treated with  captopril did not decrease  in the second day in Avoiding dark（P>0.05）,the error times of mice treated  with captopril  did not decrease in the first day and in the second day,the latency did not prolong in the second day in Step-down（P>0.05）.The biochemical results showed that the content of  Ach in the brain was significantly increased (P<0.01),the AchE content was also increased(P<0.05) in mice treated with  captopril compared with control group.Conclusion Taking captopril for a long time may promote the function of  learning and memory in normal adult mice.

Key words: captopril;learning and memory, adult mice