Abstract:

Abstract:Objective
To detect the level of serum  human epididymis protein 4(HE4) in the  patients  with ovarian cancer and approach the significance of serum  HE4  in the diagnosis
of  ovarian cancer.Methods ELISA mothod was used to detect the levels of serum  HE4   in  ovarian cancer group,benign ovarian tumor group,other malignant gynecology tumor group and malignant tumor of other organs group.The changes of the serum HE4 level   in ovarian cancer group before and  after operation were detected.The effects of  the serum HE4 level and CA215 level  in  ovarian cancer group    in the diagnois of  ovarian cancer were compared.Results The serum  HE4 levels ovarian cancer group was (242.76±113.40)pmol.L^-1 and the positive rate was 70.59％,they were higher than those in  benign ovarian tumor group（85.57 pmol.L^-1±63.40 pmol.L^-1,7.02％）,other malignant gynecology tumor group （73.16 pmol.L^-1±12.27 pmol.L^-1,0.00％），malignant tumor of other organs group（80.65 pmol?L-1±16.24 pmol.L^-1,0.00％）and control group（43.95　pmol.L^-1±18.16 pmol?L-1,0.00％）（P<0.01）;the serum HE4 level in  ovarian cancer group after operation(134.83 pmol.L^-1±56.20 pmol?L-1) was lower than  before operation（242.76 pmol.L^-1±113.40 pmol.L^-1）（P<0.05）.The positive  rate of serum HE4  in the early  ovarian cancer  was higher than that of seum CA125.The sensitiveity of HE4 combined with CA125 was  higher  than each of them,the specificity of HE4 combined with CA125 was  lower than each of them(P<0.05).Conclusion The HE4 serum has important significance in the diagnosis of  ovarian cancer,especially，its sensitivity and specificity are all better than CA125 in the diagnosis of  early  ovarian cancer,the detection of  HE4 combined with CA125 can elevate the early diagnosis rate of  ovarian cancer.

Key words: human epididymis protein 4;CA125;ovarian neoplasms;euzyme linked immunosorbent assay