Abstract:

Abstract:Objective
To examine the expression of insulin-like growth factor receptor 1（IGFR-1） in breast cancer tissue and its relationship with clinical parameters. Methods The expressions of IGFR-1 were detected in paraffin-embedded specimens from 34 patients with breast cancer and 28 controls with surgically proven benign breast disease with immunohistochemical method. Results The expression rate of IGFR-1 in breast cancer tissue was 76.5%,it was significantly higher than that in benign tissue (44.1%)（P<0.05）.In cancer group,there was positive correlation between the expression level of IGFR-1 and estrogen receptor (ER) and progesterone receptor (PR) (r=0.56,r=0.51,P<0.01);there was no significant relationship between IGFR-1 expression and armpit lymphatic node metastasis and clinical stages (r=0.31,r=0.18,both P>0.05).Conclusion IGFR-1 can express in most of the breast cancer tissues which  could be used as a biomarker for diagnosis and prognosis of breast cancer and   a new target for  treatment of breast cancer.

Key words: breast neoplasms;insulin-like growth factors;immunohistology