Abstract:

Abstract:Objective To detect the serum levels of cyclooxygenase-2(COX-2)in patients with  breast cancer before and after operation,and approach the relation of COX-2 with the clinicopathological characteristics of  breast cancer.Methods The  serum COX-2  expression levels  in 30 cases of breast cancer,13 cases of adenosis and 13 cases of controls  were detected by enzyme-linked immunosorbent assay (ELISA).Results The serum levels of COX-2 in pre-operative group and post-operative group were significantly higher than those in control group and adenosis group (P<0.01).The serum level of COX-2 in patients with breast cancer in pre-operative group was higher than that in post-operative group (P<0.01),the serum level of COX-2 in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(P<0.05),ER-negative patients had higher level of serum COX-2 than ER positive patients (P<0.01),the serum COX-2 level in HER-2 positive patients was higher than that in negative patients(P<0.01).Conclusion The serum level of COX-2 in breast ancer patients is significantly higher than those in normal control group and breast adenosis group.Detection of the serum level of COX-2 in patients with breast cancer can be used as a candidate diagnostic indicator and   for diagnos
is of the benign and malignant breast diseases.

Key words: breast neoplasms, cyclooxygenase-2;enzyme-linked immunosorbent assay; , clinicopathological characteristic