J4 ›› 2011, Vol. 37 ›› Issue (2): 300-303.doi: 吉林省科技厅科技发展计划项目资助课题(200905196)
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SUN Ya-dong,MA Yan
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Abstract:Objective To study the allelic and genotypic frequence distribution of RETN -420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP. Results The allelic frequencies and simple CC/GC+GG genotype inT2DM complicated with macroangiopathy group were significant different compared with ND group(P<0.01). The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P<0.05). The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P<0.05). Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.
Key words: type 2 diabetes mellites;resistin;gene polymorphism;macroangiopathy;polymerase chain reaction
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SUN Ya-dong,MA Yan. Analysis on |correlation between resistin -420C/G polymorphism and type 2 diabetes mellitus macroangiopathy in Han population of northeast China[J].J4, 2011, 37(2): 300-303.
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URL: http://xuebao.jlu.edu.cn/yxb/EN/吉林省科技厅科技发展计划项目资助课题(200905196)
http://xuebao.jlu.edu.cn/yxb/EN/Y2011/V37/I2/300
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