Abstract:

Abstract:Objective  To investigate the value of insulin releasing test (IRT) and insulin-like growth factor-Ⅰ(IGF-Ⅰ) in diagnosis and treatment of  type Ⅱ diabetes mellitus(T2DM) and clarify the relationship between them. Methods 138 T2DM patients (59 T2DM A and 79 T2DM B) and 43 cases of healthy controls  were chosen. The blood glucose,insulin at different time and fasting IGF-Ⅰ were measured. Results The level  of fasting insulin in T2DM patients was  lower than that in  control group at the same time （P<0.05）,the peak of insulin  was lower also (P<0.05) and was delayed for 30-60 min,it still contained a higher level at  180 min(P<0.05),the IGF-Ⅰ level  were lower than those in  control group and T2DM B patients(P<0.05). The level of fasting insulin was higher than that in control group,the peak was delayed for 60-120 min,the peak value was similar to  control group (P>0.05) and stayed higher level  till 180 min; The IGF-Ⅰ level was higher than those in  control group and T2DM A patients  (P<0.05). Conclusion IRT and IGF-Ⅰ can obviously show the state of  glucose metabolism. IRT combined with IGF-Ⅰ play an  important role in  diagnosis and treatment of T2DM.

Key words: typeⅡ diabetes mellitus;oral glucose tolerance test;insulin releasing test;insulin-like growth factor-Ⅰ
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