Abstract:

Abstract:Objective To study the expression of P21 protein in normal ovarian tissues,benign ovarian tumor tissues and epithelial ovarian carcinoma tissues and explore its relationship with clinicopathological features of epithelia
l ovarian carcinoma. Methods  The surgical resection specimens including 20 cases of normal ovarian tissues,20 cases of benign ovarian epithelial tumor tissues and 58 cases of o epithelial ovarian carcinoma tissues were selected,immunohistochemical staining was used to detect the expression of P21 ptotein. Results  The expression rate of P21 protein in epithelial ovarian carcinoma tissues was significantly lower than those in normal ovarian tissues and benign tumor tissues（P<0.05）,and the expression rate of P21 protein gradually decreased  with the increase of histological grade and  surgical stage,but there was no significant difference  in the expressions rate of P21 protein between different histological types（P>0.05）. Conclusion The low expression of P21 protein may contribute to the incidence and development of epithelial ovarian carcinoma,and its low expression may predict the high  malignancy of tumor, more aggressive  and poor prognosis.

Key words: ovarian neoplasms;epithelial carcinoma； P21 protein；immunohistochemistry