Abstract:

Objective
To investigate the insulin resistance (IR) and its related metabolic risk factors and to analyze the influence of IR in the different metabolic risk factors and their clusters among the Korean-Chinese and Han nationality people in Yanbian Korean Autonomous Prefecture area.Methods Six natural villages in Antu County of Yanbian Korean Autonomous Prefecture area were selected.Using epidemiological investigation methods combined with laboratory measurement,the body mess index (BMI),waist circumference (WC),blood pressure (BP), fasting blood glucose (FBG),triglycerides (TG),high density lipoprotein-cholesterol (HDL-C), and insulin levels in 7 856 persons (4 052  Korean-Chinese,3 804  Han nationality) were measured.The homeostasis model assessment (HOMA) method was used to estimate the human IR (HOMA-IR),and metabolic syndrome (MS) was detected according to the Guidelines on “Prevention and Treatment of Blood Lipid Abnormality in Chinese Adult”.Results The prevalence rate of IR was 27.6% in Korean-Chinese and that was 22.3% in Han nationality,and the prevalence rates of MS were 28.2% and 18.9%,respectively. The detection rate of IR in Korean-Chinese was increased than that in Han nationality (P<0.001).The prevalence rates of metabolic risk factors and MS were progressively increased with the increasing of the HOMA-IR levels (P<0.001).The detection rates of IR in the Korean-Chinese people with one kind of metabolic risk factor were 17.1%,25.2% in two kinds of metabolic risk factors,38.7% in three kinds of metabolic risk factors,and 68.8% in more than four kinds of metabolic risk factors; they were 15.2%,25.2%,39.2%,and 60.4% in Han nationality(P<0.001).The Logistic regression analysis results showed that the relative risks (95% CI  of hyperglycemia,central obesity,low HDL-C,high TG and high BP for IR were 26.383 (18.654,37.314),2.042 (1.647,2.532),1.994 (1.736,2.291),1.455 (1.246,1.699),and 1.188 (1.031,1.368);and there were nationality differences in the influence of IR in the metabolic risk factors. There were nationality differences in the influence of IR in the risk of MS,and the relative risks (95% CI) of MS for IR were 4.649 (3.685,5.865) and 3.750 (2.849,4.936).Conclusion The detection rates of different metabolic risk factors and the risk of MS are significantly increased  with the increasing of IR.IR has different influence in the risk of different metabolic risk factors and MS,and there are nationality differences.

Key words: insulin resistance, metabolic risk factor, metabolic syndrome, Korean-Chinese nationality