Abstract:

Objective To explore the effect of schizandrin B on lead excretion and its influence in the levels of calcium,iron,and zinc in the process of lead excretion. Methods 40 male ICR mice were randomly divided into control group (given saline and received 2%Tween by intraperitoneal injection),lead exposure group (Pb group,given 500 mg·kg^-1 lead acetate and received 2%Tween by intraperitoneal injection),schizandrin B group (SB group,given saline and received 4 mg·kg^-1 schizandrin B by intraperitoneal injection), and schizandrin B with lead group (SBPb group,given 500 mg·kg^-1 lead acetate and received 4 mg·kg^-1 schizandrin B by intraperitoneal injection),and there were 10 mice in each group.After treated for 23 d,the mice were sacrificed to measure the body weight,and the levels of lead,calcium,iron,and zinc in blood of the mice were detected by atomic absorption spectrometric method.The organ coefficients were calculated. Results Compared with control,SB and Pb group,the body weight of mice in SBPb group was decreased(P<0.05);compared with pre-treatment,the body weight of mice after treatment in control,SB,and Pb groups were increased(P<0.05).Compared with control group,the testes index and the level of lead in blood of the mice in Pb group were increased (P<0.05).Compared with control group,the level of zinc in blood of the mice in Pb group were decreased (P<0.05).Compared with SB group,the level of zinc in blood of the mice in Pb group were decreased (P<0.05).Compared with Pb group,the levels of calcium and zinc in blood of the mice in SB Pb group were increased (P<0.05). Conclusion Schizandrin B can excrete the lead in lead exposure mice and inhibit the loss of calcium,iron and zinc in the process of lead excretion.

Key words: schizandrin B, lead, microelement