口腔扁平苔藓患者心理因素与唾液脱氢表雄酮水平的关联性分析

doi:10.13481/j.1671-587x.20160119

Abstract

Abstract:

Objective: To explore the relationship between the scores of anxiety,depression and the salivary levels of dehydydroepiandrosterone(DHEA)in the patients with oral lichen planus (OLP),and to clarify the correlation between them. Methods: Thirty-one patients with erosive oral lichen planus (EOLP),40 patients with non-EOLP and 31 controls were investigated by the instruments Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),respectively.The saliva of objects in various groups was collected in the morning for the determination of DHEA levels by radioimmunoassay to explore the relationship between the scores of anxiety,depression and the salivary levels of DHEA in various groups. Results: The scores of HAMA and HAMD of the patients in EOLP group were significantly higher than those in control group and non-EOLP group(P<0.01).The level of salivary DHEA of the patients in EOLP group was lower than that in control group,but there was no significant difference between two groups(P>0.05). There were no significant differences of the scores of HAMA HAMD and the levels of salivary DHEA of the objects between non-EOLP group and control group (P>0.05).The level of salivary DHEA of the patients in EOLP group was negatively correlated with their scores of HAMA(r=-0.948)and HAMD(r=-0.966 ).The level of salivary DHEA of the patients in non-EOLP group was also negatively correlated with their scores of HAMA(r=-0.962)and HAMD(r=-0.971).Conclusion: The occurrence and development of EOLP is related to anxiety and depression,and its mechanism may be related to the decrease of salivary DHEA level in the patients with EOLP.

Key words: oral lichen planus, anxiety, depression, salivary, dehydydroepiandrosterone

CLC Number:

R781.5

MO Heng, GAO Chengzhi, WANG Shaojie. Analysis on association between psychological factors and salivary DHEA level in patients with oral lichen planus[J].Journal of Jilin University Medicine Edition, 2016, 42(01): 94-98.

References

[1] 陈谦明.口腔黏膜病学[M].3版.北京:人民卫生出版社,2008:101-102.

[2] Adami GR,Yeung AC,Stucki G,et al.Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus[J].Arch Oral Biol,2014,59(3):354-361.

[3] Viguier M,Bachelez H,Poirier B,et al.Peripheral and local human papillomavirus 16-specific CD8⁺ T-cell expansions characterize erosive oral lichen planus[J].J Invest, Dermatol,2015,135(2):418-424.

[4] Valter K,Boras VV,Buljan D,et al.The influence of psychological state on oral lichen planus[J].Acta Clin Croat,2013,52(2):145-149.

[5] Gavic L,Cigic L,Biocina LD,et al.The role of anxiety,depression,and psychological stress on the clinical status of recurrent aphthous stomatitis and oral lichen planus[J].J Oral Pathol Med,2014,43(6):410-417.

[6] Singh N,Zangmo R,Kumar S,et al.A prospective study on role of dehydroepiandrosterone (DHEA)on improving the ovarian reserve markers in infertile patients with poor ovarian reserve[J].Gynecol Endocrinol,2013,29(11):989-992.

[7] Girardi C,Luz C,Cherubini K,et al.Salivary cortisol and dehydroepiandrosterone (DHEA)levels,psychological factors in patients with oral lichen planus[J].Arch Oral Biol,2011,56(9): 864-868.

[8] Soto Arava M,Rojas Alcavaga G,Esguep A.Association between psychological disorders and the presence of oral lichen planus,burning mouth syndrome and recurrent aphthous stomatitis[J].Med Oral,2004,9(1):1-7.

[9] Thanakun S,Mtmikaankont P.Psychological profiles in a group of Thai patients with oral lichen planus[J].Mahidol Dent J,2006,26 (3):219-226.

[10] 林玲,唐国瑶.口腔扁平苔藓与情绪障碍的相关性研究[J].临床口腔医学杂志,2009,25(10): 622-625.

[11] Hirota SK,Moreno RA,Dos Santos CH,et al.Psychological profile (anxiety and depression)in patients with oral lichen planus: a controlled study[J].Minerva Stomatol,2013,62(3):51-56.

[12] Alshahrani S,Baccaglini L.Psychological screening test results for stress,depression,and anxiety are variably associated with clinical severity of recurrent aphthous stomatitis and oral lichen planus[J].J Evid Based Dent Pract,2014,14(4):206-208.

[13] Boscolo P,Youinou P,Theoharides TC,et al.Environmental and occupational stress and autoimmunity[J].Autoimmun Rev,2008,7(4):340-343.

[14] Elraiyah T,Sonbol MB,Wang Z,et al.Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA)in postmenopausal women with normal adrenal function: a systematic review and meta-analysis[J].J Clin Endocrinol Metab,2014,99(10):3536-3542.

[15] Hazeldine J,Arlt W,Lord JM.Dehydroepiandrosterone as a regulator of immune cell function[J].J Steroid Biochem Mol Biol,2010,120(2/3):127-136.

[16] Schmidt PJ,Daly RC,Bloch M,et al.Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression[J].Arch Gen Psychiatry,2005,62 (2): 154-162.

[17] Webb SJ,Geoghegan TE,Prough RA,et al.The biological actions of dehydroepiandrosterone involves multiple receptors[J].Drug Metab Rev,2006,38 (1/2): 89-116.

[18] Fernandes CS,Salum FG,Bandeira D,et al.Salivary dehydroepiandrosterone (DHEA)levels in patients with the complaint of burning mouth: a case-control study[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2009,108(4):537-543.

Analysis on association between psychological factors and salivary DHEA level in patients with oral lichen planus

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