Journal of Jilin University Medicine Edition ›› 2015, Vol. 41 ›› Issue (01): 140-144.doi: 10.13481/j.1671-587x.20150127

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Meta-analysis on effectiveness and safety of bupropion hydrochloride sustained-release tablets and fluoxetine tablets in treatment of depression

LIU Zhenjiang, QIN Ling, XU Guoliang   

  1. Department of Cardiology, First Hospital, Jilin University, Changchun 130031, China
  • Received:2014-04-24 Published:2015-01-30

Abstract:

Objective To approach the effectiveness and safety of bupropion hydrochloride sustained-release tablets and fluoxetine tablets in treatment of depression, and to provide basis for their application in clinic. Methods Computer search was performed using the Cochrane Central Register of Controlled Trial, Ovid-medline, PubMed, Embase, CNKI, WanFang, VIP, and CBM, and the randomized controlled trials(RCTs) were collected, then the retrieved studied according to predefined inclusion and exclusion criteria were screened, the quality of included studies was evaluated and RevMan 5.3 software was used for Meta-analysis. Results A total of 9 RCT and 1 106 patients were finally included.There was no difference in the effectiveness between bupropion hydrochloride sustained-release tablets and fluoxetine tablets [OR=1.13, 95%CI (0.87, 1.48), P>0.05].There was no difference in the side effects between bupropion hydrochloride sustained-release tablets and fluoxetine tablets [OR=1.13, 95%CI(0.91, 1.41), P>0.05]. Conclusion Bupropion hydrochloride sustained-release tablets have the same effectivenessand side effects as fluoxetine tablets in treatment of depression.

Key words: bupropion hydrochloride sustained-release tablets, fluoxetine tablets, depression, Meta-analysis

CLC Number: 

  • R749.4