Journal of Jilin University Medicine Edition ›› 2016, Vol. 42 ›› Issue (02): 351-357.doi: 10.13481/j.1671-587x.20160230

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Evaluation on efficacy of trastuzumab combined with neoadjuvant chemotherapy in Her-2 positive breast cancer patients and analysis of influencing factors of prognosis

SHAO Wanting, FU Tong, WU Panpan, WU Di, LI Sijie, ZHENG Chao, FAN Zhimin   

  1. Department of Breast Surgery, First Hospital, Jilin University, Changchun 130021, China
  • Received:2015-11-01 Published:2016-03-31

Abstract:

Objective: To assess the efficacy of trastuzumab combined with neoadjuvant chemotherapy in the treatment of human epidermal growth factor receptor-2 (Her-2) positive breast cancer patients, and to explore its influencing factors of prognosisof breast cancer.Methods: The clinical materials of 112 Her-2 positive breast cancer patients were collected and they were divided into combined treatment group (trastuzumab+neoadjuvant chemotherapy) and single chemotherapy group (without trastuzumab).SPSS 19.0 software was employed to calculate and analyze their clinical characteristics.The survival rate and prognosis were analyzed by Kaplan-Meier method, Log-rank test, and Cox regression.Results: Among the 112 Her-2 positive breast cancer patients, 23 cases were treated with trastuzumab, 89 cases were treated without trastuzumab.The disease-free survival (DFS) in combined treatment group and single chemotherapy group had significant difference (P=0.012).And there was no significant difference of overall survival (OS) between two groups (P=0.064).The HR negative group had 18(32.7%) patients with 5-level of Miller and Payne (MP) classification which was higher than HR positive group(5/46, 10.9%) (P=0.009).In univariate analysis, the tumor size, node status at diagnosis and node status after operation were the influencing factors of DFS in the Her-2 positive breast cancer patients; the tumor size, node status at diagnosis, MP classification and node status after operation were the influencing factors of OS in the Her-2 positive breast cancer patients.The result of multivariate analysis indicated that the tumor size, node status at diagnosis, and with or without radiotherapy were the independent influencing factors of DFS and OS in the Her-2 positive breast cancer patients.Conclusion: The breast lesions in the Her-2 positive breast cancer patients with negative HR are relieved after treated with trastuzumab combined with neoadjuvant chemotherapy.The combination of trastuzumab and neoadjuvant chemotherapy can significantly improve the DFS and has a positive influence in the prognosis of Her-2 positive breast cancer patients.

Key words: breast neoplasms, human epidermal growth factor receptor 2, trastuzumab, prognosis

CLC Number: 

  • R737.9