HIF-2α在非小细胞肺癌组织中的表达及其与微血管密度、Ki67和GST-π的关系

doi:10.13481/j.1671-587x.20160522

Abstract

Abstract:

Objective: To investigate the expression of hypoxia-inducible factor-2α(HIF-2α)in non-small cell lung cancer (NSCLC) tissue, and to analyze its relationships with angiogenesis,cell proliferation and chemotherapy resistance. Methods: Total 112 cases of NSCLC and 20 cases of normal lung tissues were selected, immunohistochemical method was used to detect the expressions of HIF-2α,CD31,Ki67 and GST-π in 112 cases of cancer tissue and 20 cases of normal lung tissue,and the correlations of HIF-2α expression with microvessel density (MVD),Ki67,and GST-π were analyzed. Results: The positive expression rate of HIF-2α in NSCLC tissue was significantly higher than that in normal lung tissue(P<0.05),the expression rate of HIF-2α in 112 cases of NSCLC was 47.3%(53/112). The MVD in HIF-2α protein high expression NSCLC group (31.1±14.7) was higher than that in HIF-2α protein low expression NSCLC group(24.3±15.8)(P<0.05). The cases of high expression of Ki67 in HIF-2α high expression group occupied 54.7% (29/53), and it was higher than that in HIF-2α low expression group(16/59,27.1%);there was significant difference(r=0.281,P=0.003).The high expression of HIF-2α had no obvious correlation with the expression of GST-π(r=0.122,P=0.202). Conclusion: HIF-2α may play an important role in the carcinogenesis and development of NSCLC by promoting the angiogenesis and enhancing the cell proliferation of NSCLC, but it may have no correlation with chemotherapy resistance.

Key words: cancer,non-small cell lung, hypoxia-inducible factor-2α, angiogenesis, Ki67, GST-π

CLC Number:

R734.2

YUN Fen, JIA Yongfeng, HAN Zhao, SUN Qinnuan, LI Xiuxia, YU Huiling. Expression of HIF-2αin non-small cell lung cancer tissue and its relationships with MVD,Ki67,and GST-π[J].Journal of Jilin University Medicine Edition, 2016, 42(05): 954-957.

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Expression of HIF-2αin non-small cell lung cancer tissue and its relationships with MVD,Ki67,and GST-π

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