Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (4): 1014-1021.doi: 10.13481/j.1671-587X.20210427
• Clinical medicine • Previous Articles Next Articles
Tianyi WANG1,Yufeng ZHU1,Miao SUN1,Wei WANG1,2()
Received:
2020-11-30
Online:
2021-07-28
Published:
2021-07-22
Contact:
Wei WANG
E-mail:blueskydavid@163.com
CLC Number:
Tianyi WANG,Yufeng ZHU,Miao SUN,Wei WANG. Application of three-dimensional reconstruction combined with indocyanine green intraoperative navigation in diagnosis and treatment of liver cancer[J].Journal of Jilin University(Medicine Edition), 2021, 47(4): 1014-1021.
Tab.1
Clinical materials of patients in two groups"
Group | n | Gender | Age(year) | Hepatitis | Cirrhosis | ||
---|---|---|---|---|---|---|---|
Female | Male | ||||||
Conventional | 36 | 14 | 22 | 59.17±9.24 | 16 | 14 | |
Combined | 34 | 16 | 18 | 54.18±14.42 | 14 | 18 | |
t/χ2 | 0.477 | -1.713 | 0.076 | 1.391 | |||
P | 0.490 | 0.092 | 0.782 | 0.238 | |||
Group | n | Child-pugh classification | AFP (≥400 μg·L-1) | Number of lesions | |||
A | B | ||||||
Conventional | 36 | 33 | 3 | 7 | 9 | ||
Combined | 34 | 32 | 2 | 7 | 7 | ||
t/χ2 | 0.000 | 0.014 | 0.193 | ||||
P | 1.000 | 0.905 | 0.660 |
Tab.3
Intraoperative conditions, time of postoperative hospital stay, complications and postoperative reexamination results of patients in two groups"
Group | n | Operation time (t/min) | Intraoperative blood loss (V/mL) | Number of blood transfusion (n) | ||||
---|---|---|---|---|---|---|---|---|
Conventional | 36 | 186.94±60.15 | 100(368) | 8 | ||||
Combined | 34 | 161.76±40.58 | 150(225) | 4 | ||||
t/χ2 | -2.041 | -0.448 | 1.346 | |||||
P | 0.045 | 0.654 | 0.246 | |||||
Group | n | Time of postoperative hospital stay (t/d) | Bile leakage | Hepatic failure | Postoperative hemorrhage | |||
Conventional | 36 | 11.58±4.96 | 4 | 1 | 2 | |||
Combined | 34 | 9.74±2.99 | 1 | 0 | 0 | |||
t/χ2 | -1.305 | 0.743 | 0.000 | 0.458 | ||||
P | 0.192 | 0.389 | 1.000 | 0.499 | ||||
Group | n | Clavien-Dindo classification | R0 resection | Recurrence | ||||
GradeⅠ | Grade Ⅱ | Grade Ⅲ | Grade Ⅳ | Grade Ⅴ | ||||
Conventional | 36 | 3 | 9 | 1 | 0 | 2 | 36 | 1 |
Combined | 34 | 7 | 3 | 0 | 0 | 1 | 34 | 0 |
t/χ2 | -2.005 | 0.000 | ||||||
P | 0.045 | 1.000 |
1 | 陈孝平, 裴有亮, 张万广. 腹腔镜肝癌根治术的热点与未来发展[J]. 中华普外科手术学杂志(电子版), 2019,13(3): 217-219. |
2 | 董家鸿, 黄志强. 精准肝切除: 21世纪肝脏外科新理念[J]. 中华外科杂志, 2009, 47(21): 1601-1605. |
3 | 庞飞雄, 赖彦华, 黄晓春, 等. 精准肝脏外科理念下解剖性肝切除治疗肝细胞癌的临床疗效分析[J]. 中国临床新医学, 2020, 13(5): 474-478. |
4 | UNNO N, INUZUKA K, SUZUKI M, et al. Preliminary experience with a novel fluorescence lymphography using indocyanine green in patients with secondary lymphedema[J]. J Vasc Surg, 2007,45(5): 1016-1021. |
5 | ZROBACK C, CHOW G, MENEGHETTI A, et al. Fluorescent cholangiography in laparoscopic cholecystectomy: the initial Canadian experience[J]. Am J Surg, 2016,211(5): 933-937. |
6 | MARSHALL M V, RASMUSSEN J C, TAN I C,et al.Near-infrared fluorescence imaging in humans with indocyanine green: a review and update[J]. Open Surg Oncol J, 2010, 2(2): 12-25. |
7 | ISHIZAWA T, FUKUSHIMA N, SHIBAHARA J, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging[J]. Cancer, 2009,115(11): 2491-2504. |
8 | GOTOH K, YAMADA T, ISHIKAWA O, et al. A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation[J]. J Surg Oncol, 2009,100(1): 75-79. |
9 | 陈炉良, 陆才德. 吲哚菁绿荧光造影在肝胆外科手术中的应用进展[J]. 浙江医学, 2018, 40(5):534-536, 546. |
10 | 吕少诚, 贺 强. 吲哚菁绿分子荧光影像技术在精准肝切除术中的应用现状[J]. 国际外科学杂志, 2019, 46(2): 81-84. |
11 | KUDO H, ISHIZAWA T, TANI K, et al. Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy[J]. Surg Endosc, 2014,28(8): 2504-2508. |
12 | 罗树宾, 毛家玺, 刘 聪, 等. 三维可视化技术在肝癌肝切除术前评估中的应用[J]. 中华肝脏外科手术学电子杂志, 2020, 9(2): 131-136. |
13 | SHUBERT C R, HABERMANN E B, TRUTY M J, et al. Defining perioperative risk after hepatectomy based on diagnosis and extent of resection[J]. J Gastrointest Surg, 2014, 18(11): 1917-1928. |
14 | CHINESE S O D M, CANCER COMMITTEE OF CHINESE MEDICAL DOCTOR ASSOCIATION LIVER, PRECISION MEDICINE COMMITTEE OF CHINESE MEDICAL DOCTOR ASSOCIATION CLINICAL, et al. Clinical practice guidelines for precision diagnosis and treatment of complex liver tumor guided by three-dimensional visualization technology (version 2019)[J]. Nan Fang Yi Ke Da Xue Xue Bao, 2020, 40(3): 297-307. |
15 | ÜLGER B V, HATIPOĞLU E S, ERTUĞRUL Ö, et al. Variations in the vascular and biliary structures of the liver: a comprehensive anatomical study[J]. Acta Chir Belg, 2018, 118(6): 354-371. |
16 | NAKAMURA S, TSUZUKI T. Surgical anatomy of the hepatic veins and the inferior vena cava[J]. Surg Gynecol Obstet, 1981, 152(1): 43-50. |
17 | 张中林, 李晓勉, 李 锟, 等. 吲哚菁绿荧光成像在腹腔镜肝脏外科手术中的应用[J]. 中华肝胆外科杂志, 2019,25(2): 81-86. |
18 | 张树庚, 刘连新. 吲哚菁绿荧光融合影像引导技术在腹腔镜肝切除中的应用及展望[J]. 中华肝胆外科杂志, 2019,25(2): 129-131. |
19 | 梁 霄, 翟淑亭, 梁岳龙, 等. 荧光导航腹腔镜肝脏肿瘤切除吲哚菁绿术前给药时机:单中心60例经验[J]. 中华肝胆外科杂志, 2019,25(2): 90-93. |
20 | 中国研究型医院学会微创外科学专业委员会《腹腔镜外科杂志》. 吲哚菁绿荧光染色在腹腔镜肝切除术中应用的专家共识[J].腹腔镜外科杂志,2019,24(5):388-394. |
21 | CLAVIEN P A, BARKUN J, DE OLIVEIRA M L, et al. The Clavien-Dindo classification of surgical complications: five-year experience[J]. Ann Surg, 2009,250(2): 187-196. |
22 | KOCH M, GARDEN O J, PADBURY R, et al. Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery[J].Surgery,2011,149(5): 680-688. |
23 | RAHBARI N N, GARDEN O J, PADBURY R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS)[J]. Surgery, 2011,149(5): 713-724. |
24 | RAHBARI N N, GARDEN O J, PADBURY R, et al. Post-hepatectomy haemorrhage: a definition and grading by the International Study Group of Liver Surgery (ISGLS)[J]. HPB (Oxford), 2011, 13(8): 528-535. |
25 | 杨 立,徐 臻,任琛琛,等.吲哚菁绿荧光显影在单孔腹腔镜下深部浸润型子宫内膜异位症病灶切除术中的应用[J].郑州大学学报(医学版),2020,55(3): 426-430. |
26 | ISHIZAWA T, MASUDA K, URANO Y, et al. Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma[J]. Ann Surg Oncol, 2014, 21(2): 440-448. |
27 | MARTIN A N, NARAYANAN S, TURRENTINE F E,et al. Clinical factors and postoperative impact of bile leak after liver resection[J]. J Gastrointest Surg, 2018, 22(4): 661-667. |
28 | ANDREATOS N, AMINI N, GANI F, et al. Albumin-bilirubin score: predicting short-term outcomes including bile leak and post-hepatectomy liver failure following hepatic resection[J]. J Gastrointest Surg, 2017, 21(2): 238-248. |
29 | TRUANT S, AMRANI MEL, SKRZYPCZYK C,et al. Factors associated with fatal liver failure after extended hepatectomy[J]. HPB (Oxford),2017, 19(8):682-687. |
30 | 陈 龙, 李 钺. 肝切除术后并发症的危险因素及预测评分系统[J]. 临床肝胆病杂志, 2019, 35(1): 217-221. |
31 | GOUBRAN H A, ELEMARY M, RADOSEVICH M,et al. Impact of transfusion on cancer growth and outcome[J]. Cancer Growth Metastasis, 2016, 9: 1-8. |
32 | QI C, ZHANG H, CHEN Y, et al. Effectiveness and safety of indocyanine green fluorescence imaging-guided hepatectomy for liver tumors: a systematic review and first meta-analysis[J]. Photodiagn Photodyn Ther, 2019, 28: 346-353. |
33 | KOBAYASHI Y, KAWAGUCHI Y, KOBAYASHI K,et al. Portal vein territory identification using indocyanine green fluorescence imaging: Technical details and short-term outcomes[J]. J Surg Oncol, 2017, 116(7): 921-931. |
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