Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (6): 1502-1509.doi: 10.13481/j.1671-587X.20210621
• Research in clinical medicine • Previous Articles Next Articles
Shuzhen LI1,Yajie CAO1,Haiying GENG1,Zengxiaorui CAI1,Chunmei DAI2,Youfeng WEN3,4,Ning LI1,3,4()
Received:
2021-04-29
Online:
2021-11-28
Published:
2021-12-14
Contact:
Ning LI
E-mail:157026753@qq.com
CLC Number:
Shuzhen LI,Yajie CAO,Haiying GENG,Zengxiaorui CAI,Chunmei DAI,Youfeng WEN,Ning LI. Bioinformatics analysis based on expression level of HMMR in lung adenocarcinoma tissue and its impact on prognosis of LUAD patients[J].Journal of Jilin University(Medicine Edition), 2021, 47(6): 1502-1509.
Tab. 1
Correlations between expression of HMMR and clinicopathological parameters of patients"
Clinicopathological parameter | Total (n) | OR (95%CI) | P |
---|---|---|---|
TNM stage (Ⅱ vs Ⅰ) (Ⅲ vs Ⅰ) (Ⅳ+Ⅲ vs Ⅰ+Ⅱ) M stage (M0 vs M1) N stage (Yes vs No) T stage (T1 vs T4) Age Gender (Male vs Female) | 398 361 504 369 501 337 337 337 | 2.06(1.33-3.19) 2.06(1.43-3.92) 2.08(1.34-3.26) 2.25(0.97-5.64) 2.26(1.55-3.32) 1.88(1.18-10.02) 0.98(0.96-1.00) 1.51(0.98-2.33) | 0.001 0.001 0.001 0.066 <0.01 0.012 0.123 0.057 |
Tab. 2
Associations between OS and clinicopathologic parameters of LUAD patients in TCGA datatbase"
Parameter | Univariate Cox analysis | Multivariate Cox analysis | ||
---|---|---|---|---|
HR(95%CI) | P | HR(95%CI) | P | |
Age Gender TNM stage T stage N stage M stage HMMR | 1.00(0.98-1.01) 1.00(0.69-1.43) 1.64(1.39-1.93) 1.62(1.30-2.01) 1.79(1.46-2.19) 1.68(0.92-3.05) 1.60(1.32-1.94) | 0.929 0.995 <0.001 <0.001 <0.001 0.089 <0.001 | 1.31(1.14-1.65) 1.20(0.95-1.52) 1.26(0.96-1.64) 1.43(1.17-1.74) | 0.018 0.110 0.083 0.000 |
1 | CHEN R, MANOCHAKIAN R, JAMES L, et al. Emerging therapeutic agents for advanced non-small cell lung cancer[J]. J Hematol Oncol, 2020, 13(1): 58. |
2 | XU J Y, ZHANG C, WANG X,et al.Integrative proteomic characterization of human lung adenocarcinoma[J]. Cell, 2020, 182(1): 245-261.e17. |
3 | HE Z C, MEI L, CONNELL M, et al. Hyaluronan mediated motility receptor (HMMR) encodes an evolutionarily conserved homeostasis, mitosis, and meiosis regulator rather than a hyaluronan receptor[J]. Cells, 2020, 9(4): 819. |
4 | TOLG C, LIU M, COUSTEILS K, et al. Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization[J]. J Biol Chem, 2020, 295(16): 5427-5448. |
5 | MISRA S, HASCALL V C, MARKWALD R R,et al. Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate the activities of inflammation and cancer[J]. Front Immunol, 2015, 6: 201. |
6 | CHEN F, ZHU X Q, ZHENG J, et al. RHAMM regulates the growth and migration of lung adenocarcinoma A549 cell line by regulating Cdc2/CyclinB1 and MMP9 genes Running title: RHAMM regulates the growth of lung adenocarcinoma cells[J]. Math Biosci Eng, 2020, 17(3): 2150-2163. |
7 | LI W, PAN T H, JIANG W, et al. HCG18/miR-34a-5p/HMMR axis accelerates the progression of lung adenocarcinoma[J]. Biomed Pharmacother, 2020, 129: 110217. |
8 | AUGUSTIN F, FIEGL M, SCHMID T, et al. Receptor for hyaluronic acid-mediated motility (RHAMM, CD168) expression is prognostically important in both nodal negative and nodal positive large cell lung cancer[J]. J Clin Pathol, 2015, 68(5): 368-373. |
9 | BARRETT T, WILHITE S E, LEDOUX P, et al. NCBI GEO: archive for functional genomics data sets: update[J]. Nucleic Acids Res, 2013, 41(database issue): D991-D995. |
10 | WANG Z, JENSEN M A, ZENKLUSEN J C. A practical guide to the cancer genome atlas (TCGA)[J]. Methods Mol Biol, 2016, 1418: 111-141. |
11 | SUN S S, FU Y, LIN J Y. Upregulation of MYBL2 independently predicts a poorer prognosis in patients with clear cell renal cell carcinoma[J]. Oncol Lett, 2020, 19(4): 2765-2772. |
12 | XIA Z, OU-YANG W, HU T, et al. Prognostic significance of CDC25C in lung adenocarcinoma: an analysis of TCGA data[J]. Cancer Genet, 2019(233/234): 67-74. |
13 | WU H R, ZHANG J. Decreased expression of TFAP2B in endometrial cancer predicts poor prognosis: a study based on TCGA data[J]. Gynecol Oncol, 2018, 149(3): 592-597. |
14 | LI C W, TANG Z F, ZHANG W J, et al. GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA[J]. Nucleic Acids Res, 2021, 49(W1): W242-W246. |
15 | CHANDRASHEKAR D S, BASHEL B, BALASUBRAMANYA S A H, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses[J]. Neoplasia, 2017, 19(8): 649-658. |
16 | CONNELL M, CHEN H, JIANG J, et al. HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development [J]. Elife, 2017, 6: e28672. |
17 | MAXWELL C A, RASMUSSEN E, ZHAN F, et al. RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma[J]. Blood, 2004, 104(4): 1151-1158. |
18 | HAMILTON S R, FARD S F, PAIWAND F F, et al. The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1, 2 that sustain high basal motility in breast cancer cells[J]. J Biol Chem, 2007, 282(22): 16667-16680. |
19 | CHU T L H, CONNELL M, ZHOU L, et al. Cell cycle-dependent tumor engraftment and migration are enabled by aurora-A[J]. Mol Cancer Res, 2018, 16(1): 16-31. |
20 | TILGHMAN J, WU H, SANG Y, et al. HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells[J]. Cancer Res, 2014, 74(11): 3168-3179. |
21 | ASSMANN V, MARSHALL J F, FIEBER C, et al. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells[J]. J Cell Sci, 1998, 111(12): 1685-1694. |
22 | GREINER J, RINGHOFFER M, TANIGUCHI M, et al. Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia[J]. Exp Hematol, 2002, 30(9): 1029-1035. |
23 | LI H, GUO L, LI J W, et al. Expression of hyaluronan receptors CD44 and RHAMM in stomach cancers: relevance with tumor progression[J]. Int J Oncol, 2000, 17(5): 927-932. |
24 | CHOI S, WANG D, CHEN X, et al. Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression[J]. Mol Cancer, 2019, 18(1): 92. |
25 | ZHANG D Y, LIU J H, XIE T, et al. Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma[J]. Int J Biol Sci, 2020, 16(15): 2812-2827. |
26 | WANG D, NARULA N, AZZOPARDI S, et al. Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma[J]. Oncotarget, 2016, 7(26): 39957-39969. |
27 | MARKASZ L, SAVANI R C, SEDIN G, et al. The receptor for hyaluronan-mediated motility (RHAMM) expression in neonatal bronchiolar epithelium correlates negatively with lung air content[J]. Early Hum Dev, 2018, 127: 58-68. |
28 | SONG J M, IM J, NHO R S, et al. Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells[J]. Mol Carcinog, 2019, 58(3): 321-333. |
29 | YANG D, MA Y, ZHAO P, et al. Systematic screening of protein-coding gene expression identified HMMR as a potential independent indicator of unfavorable survival in patients with papillary muscle-invasive bladder cancer[J]. Biomed Pharmacother, 2019, 120: 109433. |
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