Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (5): 1229-1236.doi: 10.13481/j.1671-587X.20210521

• Research in clinical medicine • Previous Articles     Next Articles

Bioinformatic analysis on expression characteristics of PRPS2 and its relationship with prognosis of breast cancer

Yang YU1,Sainan LIU2,Yunkai LIU1,Yong LI2,Yichun QIAO2,Yi CHENG1()   

  1. 1.Institute of Translational Medicine,First Hospital,Jilin University,Changchun 130021,China
    2.Department of Epidemiology and Health Statistics,School of Public Health,Jilin University,Changchun 130021,China
  • Received:2021-02-12 Online:2021-09-28 Published:2021-10-26
  • Contact: Yi CHENG E-mail:chengyi@jlu.edu.cn

Abstract: Objective

To investigate the expressions of phosphoribosyl pyrophosphate synthetases 2 (PRPS2) in different subtypes of breast cancer and its relationship with the prognosis of breast cancer.

Methods

The transcription levels of PRPS2 in the pan-breast cancer and normal breast tissues were investigated using GEPIA database. Furthermore, UALCAN database was used to analyze the expressions of PRPS2 in the breast cancer and normal breast tissues on the basis of age, menopause status, different subtypes, histologic subtypes, pathological stages, and nodal metastasis status. miRTarBase database was used to predict the miRNAs binding with 3' un-translated region (3'UTR) of PRPS2. Kaplan-Meier plotter database was used to evaluate the relationships between the miRNAs binding with PRPS2 andPRPS23'UTR and the prognosis of breast cancer.

Results

Compared with normal breast tissue,the expression levels of PRPS2 mRNA in different subtypes of breast cancer tissue was significantly increased(P<0.05).The high expression of PRPS2 mRNA documented the poor prognosis of breast cancer. Compared with normal breast tissue,the expression levels of hsa-miR-215-5p and hsa-miR-26b-5p, the miRNAs binding with 3'UTR of PRPS2,in the different subtypes of breast cancer tissue were significantly reduced(P<0.05);moreover, the low expression levels of hsa-miR-215 and hsa-miR-26b reflected the poor prognosis of breast cancer.

Conclusion

PRPS2 is of specific expression characteristics of pan-breast cancer, suggesting that the axis of miR-PRPS2-prognosis of breast cancer may exist.

Key words: phosphoribosyl pyrophosphate synthetases 2, bioinformatics, breast neoplasms, prognosis, overall survival

CLC Number: 

  • Q71