Journal of Jilin University(Medicine Edition) ›› 2022, Vol. 48 ›› Issue (1): 195-202.doi: 10.13481/j.1671-587X.20220124
• Research in clinical medicine • Previous Articles Next Articles
Xiuyan YU,Ting LI,Zhanjie CONG,Wenlong WANG,Xiaowei ZHANG,Xuefeng WU()
Received:
2021-07-18
Online:
2022-01-28
Published:
2022-01-17
Contact:
Xuefeng WU
E-mail:22061185@qq.com
CLC Number:
Xiuyan YU,Ting LI,Zhanjie CONG,Wenlong WANG,Xiaowei ZHANG,Xuefeng WU. Combined detection of hMAM, SBEM and CEACAM19 mRNA in peripheral blood of breast cancer patients and its clinical significance[J].Journal of Jilin University(Medicine Edition), 2022, 48(1): 195-202.
Tab. 2
Positive expressions of hMAM, SBEM and CEACAM19 mRNA in peripheral blood of breast cancer patients with different clinicopathologic features"
Clinicopathologic feature | n | hMAM mRNA | χ2 | P | SBEM mRNA | χ2 | P | CEACAM19 mRNA | χ2 | P |
---|---|---|---|---|---|---|---|---|---|---|
Age(year) | 0.993 | 0.319 | 0.000 | 0.985 | 1.194 | 0.275 | ||||
≤ 50 | 47 | 21(44.7) | 24(51.1) | 23(48.9) | ||||||
> 50 | 57 | 20(35.1) | 29(50.9) | 34(59.6) | ||||||
Tumor size | 0.005 | 0.946 | 0.638 | 0.424 | 1.552 | 0.213 | ||||
≤ 2 cm | 25 | 10(40.0) | 11(44.0) | 11(44.0) | ||||||
> 2 cm | 79 | 31(39.2) | 42(53.2) | 46(58.2) | ||||||
TNM stage | 14.028 | 0.000 | 9.812 | 0.002 | 12.219 | 0.000 | ||||
Ⅰ+Ⅱ | 49 | 10(20.4) | 17(34.7) | 18(35.6) | ||||||
Ⅲ+Ⅳ | 55 | 31(56.4) | 36(65.5) | 39(69.5) | ||||||
LM | 0.583 | 0.445 | 8.054 | 0.005 | 8.970 | 0.003 | ||||
Yes | 69 | 29(42.0 ) | 42(60.9) | 45(65.2) | ||||||
No | 35 | 12(34.3) | 11(31.4) | 12(34.3) | ||||||
ER | 2.593 | 0.107 | 0.001 | 0.973 | 4.725 | 0.030 | ||||
Negtive | 43 | 13(30.2) | 22(51.2) | 29(67.4) | ||||||
Positive | 61 | 28(45.9) | 31(50.8) | 28(45.9) | ||||||
PR | 3.686 | 0.055 | 0.187 | 0.665 | 0.283 | 0.595 | ||||
Negtive | 45 | 13(28.9) | 22(48.9) | 26(57.8) | ||||||
Positive | 59 | 28(47.5) | 31(52.5) | 31(52.5) | ||||||
HER-2 | 11.665 | 0.001 | 1.354 | 0.245 | 0.009 | 0.924 | ||||
Negtive | 57 | 14(24.6) | 32(56.1) | 31(54.4) | ||||||
Positive | 47 | 27(57.4) | 21(44.7) | 26(55.3) | ||||||
PT | 0.810 | 0.667 | 0.981 | 0.612 | 5.281 | 0.071 | ||||
IDC | 71 | 30(42.3) | 37(52.1) | 44(62.0) | ||||||
ILC | 20 | 7(35.0) | 11(55.0) | 9(45.0) | ||||||
MC | 13 | 4(30.8) | 5(38.5) | 4(30.8) |
Tab. 3
Positive expressions in detection of hMAM combined with SBEM and CEACAM19 mRNA in peripheral blood of subjects in three groups"
Group | n | hMAM mRNA | hMAM mRNA+SBEM mRNA | hMAM mRNA+CEACAM19 mRNA | hMAM mRNA+SBEM mRNA+CEACAM19 mRNA |
---|---|---|---|---|---|
Healthy control | 50 | 0(0.0) | 4(8.0) | 6(12.0) | 8(16.0) |
Benign breast disease | 52 | 3(7.9) | 9(17.3) | 12(23.1) | 14(26.9) |
Breast cancer | 104 | 41(39.4)*△ | 65(62.5)*△ | 66(63.5)*△ | 69(66.3)*△ |
Tab. 4
Positive expressions in detection of hMAM combined with SBEM and CEACAM19 mRNA in peripheral blood of breast cancer patients at different TNM stages [n(η/%)]"
TNM stage | n | hMAM mRNA | hMAM mRNA+SBEM mRNA | hMAM mRNA+CEACAM19 mRNA | hMAM mRNA+ SBEM mRNA+ CEACAM19 mRNA |
---|---|---|---|---|---|
Ⅰ+Ⅱ | 49 | 10(20.40) | 21(42.86) | 22(44.90) | 24 (48.98) |
Ⅲ+Ⅳ | 55 | 31(56.36) | 44(80.00) | 44(80.00) | 45 (81.82) |
χ2 | 14.028 | 15.253 | 13.770 | 12.515 | |
P | <0.01 | <0.01 | <0.01 | <0.01 |
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