Abstract:

Methods The clinical manifestations of one patient with ITTC were observed.The general morphology of the tumor was observed with naked eyes， laboratory examination and imaging examination were performed， the fine needle aspiration cytology of the thyroid tumor was observed， the morphology of the tumor tissue was observed under light microscope， immunohistochemistry staining and in situ hybridization were performed in the tumor tissue， and the patient was followed up 3 and 11 months after operation；the relevant literatures were reviewed. Results The main clinical manifestation of the ITTC patient was a slightly hard mass in the thyroid.The fine needle aspiration cytology results showed that the tumor cells showed a three-dimensional structure，and the prominent nucleoli could be seen in some cells. The histology results showed that the cancer cells were nest like or island like and differentiated into the squamous cells； the fibrous tissue proliferated accompanying with lymphocyte infiltration around the cancer cells and the right cervical lymph node metastasis. The immunophenotype detection results showed that the cancer cells expressed CD117， CD5 and P63， but didn’t express TdT and TTF-1，EBER-ISH （－）. The pathological diagnosis was ITTC accompanying with cervical lymph node metastasis. No recurrence or metastasis was found on CT 3 and 11 months after operation. Conclusion ITTC has low malignancy degree，which can relapse and metastasize，and combined with surgery and radiotherapy， the prognosis of the patients is good. Objective To study the clinicopathological features， treatment method and prognosis of intrathyroid thymic carcinoma （ITTC），and to strengthen the clinicans’ understandings of the disease.

Key words: Thymus gland, Intrathyroid thymic carcinoma, Carcinoma showing thymus-like differenitiation, Introthyroid epithelial thymoma, Immunophenotyping