miRNA对新生儿缺氧缺血性脑损伤保护作用的研究进展

doi:10.13481/j.1671-587X.20250532

Abstract

Abstract:

Hypoxic-ischemic brain damage （HIBD） is a leading cause of neonatal mortality and neurological dysfunction in the infants， and it remains a focal point of research in neonatology. MicroRNA （miRNA） is involved in neural development， and its alterations is closely associated with the pathological progression of HIBD. However， there is a lack of effective integration of studies on the specific roles and mechanisms of miRNAs at different pathological stages of the disease. This review summarized the recent researches on miRNA in various stages of HIBD. During the hypoxic-ischemic phase， abnormal expression of certain hypoxia-related miRNA can serve as novel biological diagnostic markers. In the cerebral edema phase， miRNA may maintain the integrity of the blood-brain barrier， alleviating neuronal swelling and structural changes. In the cerebral infarction phase， miRNA can inhibit the expression of apoptotic proteins， enhance the neuronal survival rates， reduce the infarct size， and improve neurological behavior. Further research into the mechanisms of miRNA in HIBD will provide new insights for the development of diagnostic and therapeutic strategies for HIBD.

Key words: Hypoxic-ischemic brain damage, Pathogenesis, MicroRNA, Newborn, Neuroinflammation

CLC Number:

R272.1

Guang YANG,Zhifang ZHENG,Xinhua ZHANG. Research progress in protective effect of miRNA on neonatal hypoxic-ischemic brain injury[J].Journal of Jilin University(Medicine Edition), 2025, 51(5): 1423-1428.

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Research progress in protective effect of miRNA on neonatal hypoxic-ischemic brain injury

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